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Striatin-Dependent Membrane Estrogen Receptor Signaling and Vasoprotection by…
Estrogen activates multiple signaling pathways in most target cells and tissues, including those within the cardiovascular system. Functional ERs, ER and ER, are expressed on cardiomyocytes in the heart and by endothelial and smooth muscle cells within blood vessels. Early studies indicated that ERs are ligand-activated transcription factors, which exist primarily in the nucleus complexed wi…
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Aldosterone’s Rapid, Nongenomic Effects Are Mediated by Striatin: A Modulat…
The cellular responses to steroids are mediated by 2 general mechanisms: genomic and rapid/ nongenomic effects. Identification of the mechanisms underlying aldosterone (ALDO)’s rapid vs their genomic actions is difficult to study, and these mechanisms are not clearly understood. Recent data suggest that striatin is a mediator of nongenomic effects of estrogen. We explored the hypothesis that …
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Inositol – Clinical Applications for Exogenous Use
Recent advances in nutritional and biochemical research have documented inositol as an important dietary and cellular constituent. The processes involved in inositol metabolism and its derivatives in the tissues of mammals have been characterized in vivo as well as at the enzymatic level. Biochemical functions defined for phosphatidylinositol in biological membranes include the regulation of ce…
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Potential effect of striatin (DLBS0333), a bioactive protein fraction isolate…
Striatin contained four major bioactive proteins with approximate molecular weight of 8.3, 10.9, 15.4 and 16.7 kDa. In addition to proteins, striatin also contained amino acids (10 essential and 7 non essential amino acids), fatty acids (palmitic acid, oleic acid, stearic acid, linoleic acid, arachidonic acid), vitamins (vitamin A, vitamin B6) and other nutrients (carbohydrate, dietary fiber, b…
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Channa striatus capsules induces cytokine conversion in pulmonary tuberculosi…
The rate of positive sputum smear decline was more pronounced in the Channa striatus group but did not reach statistically different value between groups. The levels of TNF-α, IFN-γ, and IL-10 were not significantly different in Channa striatus group compared to placebo group at baseline (week 0). But at week 12, the supplementation of Channa striatus capsule significantly decreased TNF-α, I…
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Preeclampsia Induced Ocular Change
Preeclampsia/eclampsia, the most common medical complication of pregnancy, can affect visual system as an end organ damage. Visual symptoms occur in 25% of patients with severe preeclampsia and 50% of patients with eclampsia. Visual system may be affected by hypertensive retinopathy, exudative retinal detachment, and cortical blindness.
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Effect of dietary protein intake on albumin homeostasis in nephrotic patients
Animals with experimental renal disease maintained on dietsrest ricted in protein develop less severe renal lesions and less proteinuria than do animals maintained on a normal or high protein diet. To determine whether restriction of dietary protein will reduce urinary albumin excretion in patients with established nephroses and whether such dietary restriction will result in decreased albumi…
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Pre-Eclampsia Increases the Risk of Postpartum Haemorrhage A Nationwide Cohor…
Postpartum haemorrhage is a leading cause of maternal morbidity and mortality worldwide. Identifying risk indicators for postpartum haemorrhage is crucial to predict this life threatening condition. Another major contributor to maternal morbidity and mortality is pre-eclampsia. Previous studies show conflicting results in the association between preeclampsia and postpartum haemorrhage. The p…
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Pre-Eclampsia and Eclampsia: An Update on the Pharmacological Treatment Appli…
Pre-eclampsia and eclampsia are two hypertensive disorders of pregnancy, considered major causes of maternal and perinatal death worldwide. Pre-eclampsia is a multisystemic disease characterized by the development of hypertension after 20 weeks of gestation, with the presence of proteinuria or, in its absence, of signs or symptoms indicative of target organ injury. Eclampsia represents the con…
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Intrauterine Devices: An Update
Three intrauterine devices (IUDs) are available in the United States: the copper T 380A and two levonorgestrel-releasing IUDs, one that releases 20 mcg of levonorgestrel per 24 hours, and one that releases 14 mcg per 24 hours. All are safe and effective methods of contraception that work predominantly by prefertilization mechanisms. The copper T 380A IUD may be placed in nonpregnant women at an…
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