Animals with experimental renal disease maintained on dietsrest ricted in protein develop less severe renal lesions and less proteinuria than do animals maintained on a normal or high protein diet. To determine whether restriction of dietary protein will reduce urinary albumin excretion in patients with established nephroses and whether such dietary restriction will result in decreased albumi…
Nephrotic syndrome is caused by urinary loss of proteins of intermediate size. Albumin protein is lost in the greatest quantity, but important protein-bound nutrients-such as iron bound to transferrin, vitamin D bound to vitamin D-binding protein, copper bound to ceruloplasmin, and zinc bound mostly to albumin-are lost as well. The syndrome is characterized by hypoalbuminemia, edema formation, …