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The Influence of Molecular Size on Drug Absorption: A Comprehensive Overview
The process of drug absorption is a critical determinant in the pharmacokinetics of therapeutic agents. Among the various factors influencing drug absorption, the molecular size stands out as a key parameter. This article delves into how molecular size affects drug absorption, exploring the mechanisms involved, the challenges presented, and the strategies employed to optimize drug delivery for …
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Hydration-Induced Structural Changes in the Solid State of Protein:A SAXS/WAX…
The stability of biologically produced pharmaceuticals is thelimiting factor to various applications, which can be improved by formulationin solid-state forms, mostly via lyophilization. Knowledge about the proteinstructure at the molecular level in the solid state and its transition uponrehydration is however scarce, and yet it most likely affects the physical andchemical stability of the biol…
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Pharmaceutical Coating and Its Different Approaches, a Review
Coating the solid dosage form, such as tablets, is considered common, but it is a critical process that provides different characteristics to tablets. It increases the value of solid dosage form, administered orally, and thus meets diverse clinical requirements. As tablet coating is a process driven by technology, it relies on advancements in coating techniques, equipment used for the coating …
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Potential effect of striatin (DLBS0333), a bioactive protein fraction isolate…
To characterize proteins and other nutrients in striatin (DLBS0333), a bioactive protein fraction isolated from snakehead fish (Channa striata) and to investigate its wound healing activity
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Randomized Controlled Trial on the Effect of Channa striatus Extract on Measu…
To compare the mean of anteroposterior (AP) measurements of the uterus in longitudinal and oblique transverse planes, and the pulsatility index (PI) and resistive index (RI) of the uterine artery and superficial skin wound artery between patients taking Channa striatus and placebo.
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Channa striatus capsules induces cytokine conversion in pulmonary tuberculosi…
The rate of positive sputum smear decline was more pronounced in the Channa striatus group but did not reach statistically different value between groups. The levels of TNF-α, IFN-γ, and IL-10 were not significantly different in Channa striatus group compared to placebo group at baseline (week 0). But at week 12, the supplementation of Channa striatus capsule significantly decreased TNF-α, I…
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Preeclampsia Induced Ocular Change
Preeclampsia/eclampsia, the most common medical complication of pregnancy, can affect visual system as an end organ damage. Visual symptoms occur in 25% of patients with severe preeclampsia and 50% of patients with eclampsia. Visual system may be affected by hypertensive retinopathy, exudative retinal detachment, and cortical blindness.
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Effect of dietary protein intake on albumin homeostasis in nephrotic patients
Animals with experimental renal disease maintained on dietsrest ricted in protein develop less severe renal lesions and less proteinuria than do animals maintained on a normal or high protein diet. To determine whether restriction of dietary protein will reduce urinary albumin excretion in patients with established nephroses and whether such dietary restriction will result in decreased albumi…
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Pre-Eclampsia Increases the Risk of Postpartum Haemorrhage A Nationwide Cohor…
Postpartum haemorrhage is a leading cause of maternal morbidity and mortality worldwide. Identifying risk indicators for postpartum haemorrhage is crucial to predict this life threatening condition. Another major contributor to maternal morbidity and mortality is pre-eclampsia. Previous studies show conflicting results in the association between preeclampsia and postpartum haemorrhage. The p…
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Pre-Eclampsia and Eclampsia: An Update on the Pharmacological Treatment Appli…
Pre-eclampsia and eclampsia are two hypertensive disorders of pregnancy, considered major causes of maternal and perinatal death worldwide. Pre-eclampsia is a multisystemic disease characterized by the development of hypertension after 20 weeks of gestation, with the presence of proteinuria or, in its absence, of signs or symptoms indicative of target organ injury. Eclampsia represents the con…
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