Parecoxib sodium demonstrates gastrointestinal safety comparable to placebo i…

The gastrointestinal safety of the novel injectable cyclooxygenase-2 selective inhibitor, parecoxib sodium, was compared with the nonselective nonsteroidal anti-inflammatory drug, ketorolac, and placebo in healthy subjects.

Effects of Probiotics, Prebiotics, and Synbiotics on Human Health

The human gastrointestinal tract is colonised by a complex ecosystem of microorganisms. Intestinal bacteria are not only commensal, but they also undergo a synbiotic co-evolution along with their host. Beneficial intestinal bacteria have numerous and important functions, e.g., they produce various nutrients for their host, prevent infections caused by intestinal pathogens, and modulate a normal…

Cisapride : An Updated Review of its Pharmacology and Therapeutic Efficacy a…

Cisapride is an orally administered prokinetic agent which facilitates or restores motility throughout the length of the gastrointestinal tract. It is a substituted piperidinyl benzamide, chemically related to metoclopramide, but unlike metoclopramide, cisapride is largely devoid of central depressant or antidopaminergic effects. In placebo-controlled trials, cisapride improved healing rates an…

Comparison of the Efficacy of Tenofovir Versus Tenofovir plus Entecavir in th…

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Diagnosis of Hepatic Nodules in Patients at Risk for Q1 Hepatocellular Carcin…

Unequivocal diagnosis with avoidance of false- positive results is very relevant in patients with liver disease in whom an imaging technique detects a nodule that raises the potential emergence of hepatocellular carcinoma (HCC). Although biopsy confirmation is standard in most cancers, several studies have shown that reliable HCC diagnosis may be established by imaging techniques in patient…

Etiology of Peptic Ulcer Disease

Peptic ulcer (PU) is defect in the gastrointestinal mucosa usually located in the stomach and duodenum, but it can develop in any portion of the gastrointestinal tract that is exposed to acid and pepsin in sufficient concentration and duration. Histologically, ulcers are defined as necrotic mucosal defects that extend through the muscularis mucosa and into submucosa, whereas superficial necrot…

Evidence-based clinical practice guidelines for peptic ulcer disease 2015

The Japanese Society of Gastroenterology (JSGE) revised the evidence-based clinical practice guidelines for peptic ulcer disease in 2014 and has created an English version. The revised guidelines consist of seven items: bleeding gastric and duodenal ulcers, Helicobacter pylori (H. pylori) eradication therapy, non-eradication therapy, drug-induced ulcer, non-H. pylori, non-nonsteroidal anti-inf…

Peptic ulcer disease

The rapidly declining prevalence of Helicobacter pylori infection and widespread use of potent anti-secretory drugs means peptic ulcer disease has become substantially less prevalent than it was two decades ago. Management has, however, become more challenging than ever because of the threat of increasing antimicrobial resistance worldwide and widespread use of complex anti-thrombotic therapy i…

Clinical Application of Stem Cells in Liver Diseases: From Bench to Bedside

Advances in stem cell biology bring remarkable revolution to human disease study and therapy, including various liver diseases. The establishment of pluripotent stem cells (PSCs), especially induced pluripotent stem cells (iPSCs), makes it possible to obtain infinite hepatocytes derived from human source for cell therapy, disease modeling, and drug testing

Knowledge Sharing Session : Gastrointestinal Disturbances

Dexan sering mengalami perut kembung, mual & muntah atau nyeri lambung? Yuk, kenali dan atasi gangguan pencernaan sebelum terlambat dengan ikut sharing knowledge