Etiology of Peptic Ulcer Disease

Peptic ulcer (PU) is defect in the gastrointestinal mucosa usually located in the stomach and duodenum, but it can develop in any portion of the gastrointestinal tract that is exposed to acid and pepsin in sufficient concentration and duration. Histologically, ulcers are defined as necrotic mucosal defects that extend through the muscularis mucosa and into submucosa, whereas superficial necrot…