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Raynaud's disease
We report five children who presented with Raynaud's disease in whom we could find no clinical, haematological, or immunological evidence of a collagen disorder. Oral phenoxybenzamine proved useful for maintenance treatment in most, with infusions of prostacyclin, nitroprusside, and ketanserin during acute attacks
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Advances in radionuclide imaging of cardiac sarcoidosis
Radionuclide imaging for the diagnosis and monitoring of cardiac involvement in sarcoidosis has advanced significantly in recent years.
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EARLY FLUID RESUSCITATION OF END STAGE RENAL DISEASE PATIENTS WITH SEVERE SEP…
The Surviving Sepsis (SS) Guidelines recommend early, aggressive fluid resuscitation with 30mL/kg crystalloid for hypotension or lactate >4mmol/L within the first 3hours of suspected sepsis (t S-3). These guidelines are not always applied to septic patients with end stage renal disease (ESRD) due to fear of developing complications. We hypothesized that ESRD patients with severe sepsis (with h…
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Renin Angiotensin System and Cytokines in Chronic Kidney Disease: Clinical an…
Chronic kidney disease (CKD) has been considered an important publichealth issue in all countries. Experimental and clinical studies support the general idea that the pathophysiology of CKD is associated with the interaction of several endogenous mediators, in-cluding components of therenin-angiotensin system(RAS) and cytokines
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β-Thalassemia
β-Thalassemia is caused by reduced (β+) or absent (β0) synthesis of the β-globin chains of hemoglobin. Three clinical and hematological conditions of increasing severity are recognized: the β-thalassemia carrier state, thalassemia intermedia, and thalassemia major, a severe transfusion-dependent anemia. The severity of disease expression is related mainly to the degree of α-globin chain e…
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Silent Cerebral Embolism during Atrial Fibrillation Ablation: Pathophysiology…
Although many efforts have been directed to improve atrial fibrillation transcatheter ablation safety, thromboembolism to the brain remains one of the major complications. In fact several studies have confirmed occurrence of silent cerebral embolic lesions by post-procedure magnetic resonance imaging, the present review will focus on the possible mechanisms leading to silent cerebral embolism i…
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Fluid Resuscitation In Patients With End-Stage Renal Disease Presenting With …
In the United states 750,000 patients are diagnosed with severe sepsis every year with an average annual increase of 13.0%. Septic patients with End Stage Renal Disease (ESRD) have 100-300 fold increased mortality when compared to the general population. There has been a plethora of information about the use of fluid resuscitation in sepsis. However, there is sparse information about the use of…
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Fluid Resuscitation And Mortality In Sepsis With End-Stage Renal Disease
Patients with end-stage renal disease on dialysis (ESRD-HD) have an increased risk of sepsis and sepsis-related mortality. Professional society and government guidelines recommend weight-based initial IV fluid resuscitation targets as part of sepsis care bundles; however, there are no specific recommendations for patients with sepsis and ESRD-HD. While higher volumes of administered fluids have…
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The Renin-Angiotensin System and Progression of Renal Disease: From Hemodynam…
The renal community is faced with an ever increasing number of patients reaching end-stage renal failure. Clinical studies have provided clear evidence that angiotensin-converting enzyme (ACE) inhibitors, and probably also AT1 receptor antagonists, at least in patients suffering from type 2 diabetes, slow disease progression to end-stage renal failure.
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Renin-Angiotensin-Aldosterone System and Progression of Renal Disease
Inhibition of the renin-angiotensin-aldosterone system (RAAS) is one of the most powerful maneuvers to slow progression of renal disease. Angiotensin II (AngII) has emerged in the past decade as a multifunctional cytokine that exhibits many nonhemodynamic properties, such as acting as a growth factor and profibrogenic cytokine, and even having proinflammatory properties. Many of these delete…
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