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Timing of Renal Replacement Therapy for Severe Acute Kidney Injury in Critica…
Acute kidney injury (AKI) affects many intensive care unit patients and is responsible for increased morbidity and mortality. Although life-saving in many situations, renal replacement therapy (RRT) may be associated with complications and the appropriate timing of its initiation is still the subject of intense debate. An early initiation strategy can prevent some metabolic complications where…
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A Meta-Analysis of the Effects of Dietary Protein Restriction on the Rate of …
Dietary protein restriction has been reported to delay the need for renal replacement therapy in clinical trials and meta-analyses. However, less clear is what effect dietary protein has on the rate of decline in renal function. We pooled the results of 13 randomized controlled trials (n 5 1,919 patients) and found that dietary protein restriction reduced the rate of decline in estimated glo…
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Nutritional Management of Nephrotic Syndrome
Nephrotic syndrome is caused by urinary loss of proteins of intermediate size. Albumin protein is lost in the greatest quantity, but important protein-bound nutrients-such as iron bound to transferrin, vitamin D bound to vitamin D-binding protein, copper bound to ceruloplasmin, and zinc bound mostly to albumin-are lost as well. The syndrome is characterized by hypoalbuminemia, edema formation, …
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Nutrition and chronic kidney disease
The incidence of malnutrition disorders in chronic kidney disease (CKD) appears unchanged over time, whereas patient-care and dialysis techniques continue to progress. Despite some evidence for cost-effective treatments, there are numerous caveats to applying these research findings on a daily care basis. There is a sustained generation of data confirming metabolic improvement when patients con…
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Cellular and molecular mechanisms of renal fibrosis
Renal fibrosis, particularly tubulointerstitial fibrosis, is the common final outcome of almost all progressive chronic kidney diseases. Renal fibrosis is also a reliable predictor of prognosis and a major determinant of renal insufficiency. Irrespective of the initial causes, renal fibrogenesis is a dynamic and converging process that consists of four overlapping phases: priming, activation, e…
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Pathophysiological Mechanisms of Renal Fibrosis: A Review of Animal Models an…
Chronic kidney disease (CKD) is a long-term condition in which the kidneys do not work correctly. It has a high prevalence and represents a serious hazard to human health and estimated to affects hundreds of millions of people. Diabetes and hypertension are the two principal causes of CKD
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Redefining lupus nephritis: clinical implications of pathophysiologic subtypes
Systemic lupus erythematosus (SLE) is associated with a broad spectrum of clinical and immunologic manifestations, of which lupus nephritis is the most common cause of morbidity and mortality. The development of nephritis in patients with SLE involves multiple pathogenic pathways including aberrant apoptosis, autoantibody production, immune complex deposition and complement activation.
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Redefining lupus nephritis : Clinical Implication of Patophysiologic Subtypes.
Systemic lupus erythematosus (SLE) is associated with a broad spectrum of clinical and immunologic manifestations, of which lupus nephritis is the most common cause of morbidity and mortality. The development of nephritis in patients with SLE involves multiple pathogenic pathways including aberrant apoptosis, autoantibody production, immune complex deposition and complement activation.
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