PRODUCT LITERATURE

Effect of erdosteine on the rate and duration of COPD exacerbations: the RESTORE study

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Oxidative stress contributes to chronic obstructive pulmonary disease (COPD) exacerbations and antioxidants can decrease exacerbation rates, although we lack data about the effect of such drugs on exacerbation duration.
The RESTORE (Reducing Exacerbations and Symptoms by Treatment with ORal Erdosteine in COPD) study was a prospective randomised, double-blind, placebo-controlled study, enrolling patients aged 40–80 years with Global Initiative for Chronic Obstructive Lung Disease stage II/III. Patients received erdosteine 300 mg twice daily or placebo added to usual COPD therapy for 12 months. The primary outcome was the number of acute exacerbations during the study

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: .,

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Language

English

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NONE

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Subject(s)

VECTRINE
Erdosteine
COPD
RESTORE study

Specific Detail Info

Eur Respir J 2017; 50: 1700711

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