COPD is increasingly recognized as a leading cause of morbidity and mortality throughout the world, and imposes a considerable burden on healthcare resources. The goals of COPD management are currently to increase the time free of disease symptoms, to reduce the time spent in hospital and to improve exercise tolerance, health status and quality of life
Oxidative stress contributes to chronic obstructive pulmonary disease (COPD) exacerbations and antioxidants can decrease exacerbation rates, although we lack data about the effect of such drugs on exacerbation duration. The RESTORE (Reducing Exacerbations and Symptoms by Treatment with ORal Erdosteine in COPD) study was a prospective randomised, double-blind, placebo-controlled study, enrollin…