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Clinical Pharmacodynamics of Meropenem in Patients with Lower Respiratory Tract Infections


Studies of  -lactam pharmacodynamics in infected patients are sparse. In this study, classification and regression tree (CART) and logistic regression analyses were used to identify which pharmacodynamic indices and magnitudes were significant predictors of meropenem efficacy for 101 adult patients with lower respiratory tract infections (LRTI). Using demographic data, a validated population pharmacokinetic model was employed to predict pharmacokinetic parameters and free serum concentrations in the studied patients.


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English
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NONE
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ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, May 2007, p. 1725–1730
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