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Beyond symptomatic effects: potential of donepezil as a neuroprotective agent…
Alzheimer’s disease (AD) is associated with neurodegenerative changes resulting clinically in progressive cognitive and functional deficits. The only therapies are the cholinesterase inhibitors donepezil, galantamine and rivastigmine and the N-methyl-Daspartate-receptor antagonist memantine. Donepezil acts primarily on the cholinergic system as a symptomatic treatment, but it also has potenti…
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Clinical efficacy and safety of donepezil in the treatment of Alzheimer’s d…
Donepezil, an acetylcholinesterase inhibitor (AChEI), has been widely used to treat Alzheimer’s disease (AD) in China. However, there are few studies focusing on the efficacy and safety of donepezil in Chinese patients. In this review, we discuss 1) the efficacy of donepezil and its comparison with other AChEIs or memantine, 2) the therapeutic responses to donepezil and its influencing factor…
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Attention Measures of Accuracy, Variability, and Fatigue Detect Early Respons…
Donepezil is widely used to treat Alzheimer’s disease (AD), but detecting early response remains challenging for clinicians. Acetylcholine is known to directly modulate attention, particularly under high cognitive conditions, but no studies to date test whether measures of attention under high load can detect early effects of donepezil. We hypothesized that load-dependent attention tasks are …
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The Role of Vitamins and Minerals in Energy Metabolism and Well-Being
Physicians are frequently confronted with patients complaining of fatigue, tiredness and low energy levels. In the absence of underlying disease, these symptoms could be caused by a lack of vitamins and minerals. Certain risk groups like the elderly and pregnant women are wellrecognized. Our aim was, therefore, to find out if other, less well-established groups might also be at risk. Thus, the…
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Freeze-drying of emulsified systems: A review
Colloidal systems such as emulsions, microemulsions and nanoemulsions are able to transport active molecules, enhance their solubility and stability and minimize their side effects. However, since they are dispersions with an aqueous continuous phase they have some disadvantages such as the risk of microbiological contamination, degradation by hydrolysis, physico-chemical instability and loss o…
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The Psychology of Money: Timeless lessons on wealth, greed, and happiness
Pernahkah Anda merasa kalau uang yang Anda kumpulkan selama bekerja tidak Anda rasakan manfaatnya? Atau seberapa banyak pun uang yang Anda punya tidak membuat Anda merasa puas? Bisa jadi masalahnya bukan pada uang, tapi pada diri Anda. Untuk itu, buku “The Psychology of Money” hadir untuk menjembatani urusan psikologis Anda dan uang yang Anda miliki. Buku “The Psychology of Money” ka…
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Nanoemulsion: an advanced mode of drug delivery system
An advanced mode of drug delivery system has been developed to overcome the major drawbacks associated with conventional drug delivery systems. This review gives a detailed idea about a nanoemulsion system. Nanoemulsions are nano-sized emulsions, which are manufactured for improving the delivery of active pharmaceutical ingredients. These are the thermodynamically stable isotropic system in w…
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Single-dose i.v. granisetron in the prevention of postoperative nausea and vo…
In this randomized, double-blind, parallel group, placebo-controlled, dose-ranging study, we have compared three doses (0.1 mg, 1.0 mg and 3.0 mg) of the 5-HT3 receptor antagonist, granisetron (Kytril), as prophylactic therapy for the prevention of postoperative nausea and vomiting. The aims were to determine the optimal dose of granisetron and to evaluate its safety profile. We studied 527 adu…
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The Cardiotoxic Potential of the 5-HT3 Receptor Antagonist Antiemetics: Is Th…
To review and evaluate the potential cardiac effects of 5-HT3 antiemetic treatment in patients who may be predisposed to cardiac complications resulting from malignancy, cytotoxic oncologic regimens, or preexisting comorbid conditions
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Granisetron: An Update on its Clinical Use in the Management of Nausea and Vo…
Nausea and vomiting are typical side effects of cytotoxic therapy and some surgical procedures. These symptoms can represent a major therapeutic challenge and, if inadequately controlled by antiemetic treatment, will result in increased mortality, morbidity, and health care costs. However, the management of nausea and vomiting has improved greatly in recent years following the introduction of t…
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