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Efficacy and safety of nebivolol in elderly heart failure patients with impai…
SENIORS recruited patients aged 70 years or older with symptomatic HF, irrespective of ejection fraction, and randomized them to nebivolol or placebo. Patients (n ¼ 2112) were divided by tertile of estimated glomerular filtration rate (eGFR). Mean age of patients was 76.1 years, 35% of patients had an ejection fraction of .35%, and 37% were women resulting in a unique cohort, far more represe…
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Benefits and safety of candesartan treatment in heart failure are independent…
Ageing may affect drug efficacy and safety in patients with heart failure (HF). The Candesartan in Heart ailureAssessment of Reduction in Mortality and morbidity (CHARM) programme offered an opportunity to study the relationship between increasing age and the efficacy and safety of treatment in an uniquely broad spectrum of patients with symptomatic HF and either reduced or preserved left vent…
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