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Clinical Efficacy of Pitavastatin, a New 3-Hydroxy-3-methylglutaryl Coenzyme …
Pitavastatin (CAS 147526-32-7, NK-104), the first totally synthetic 3-hydroxy-3- methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor discovered in Japan, was examined. Pitavastatin significantly decreased the serum levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) at doses of 1 mg/day or more, and significant dose-dependence of the effect of this drug was ob…
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Comparison of the Lipid-Lowering Effects of Pitavastatin 4mg Versus Pravastat…
Results froma Phase III, European, non-inferiority trial in elderly (age Z65 years) patients with primary hyperlipidemia or mixed(combined) dyslipidemia demonstrated significantly greater reductions in LDL-C for pitavastatin versus pravastatin across 3pair-wise dose comparisons (1mgvs10mg,2 mgvs20mg, and4mgvs40mg, respectively). The present study investigated whether pitavastatin 4mg is superi…
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New Formulation of Fast-Melting Tablets: Vometa FT as a Case Study
The demand of fast-melting tablets has been growing during the last decade. This dosage form is placed in the mouth, allowed to disperse or dissolve in the saliva, and then swallowed. In addition, it can be administered anywhere, without the need for water or chewing. Due its features, the fast-melting tablets will increase patient compliance, especially those who need rapid relief, such as vom…
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Cardiac Safety and Clinical Efficacy of High Dose Domperidone for Long-Term T…
Domperidone (D), a dopamine 2 receptor antagonist, is an effective anti-emetic that acts at the chemoreceptor trigger zone and only minimally crosses the blood brain barrier while also exerting prokinetic effects on the stomach and proximal small bowel. D is not approved in the USA. Recommended dosing worldwide is 30 mg/day and due to scattered reports of cardio toxicity ECG monitoring is reco…
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Effect of Domperidone on the Health-Related Quality of Life of Patients With …
To describe the health-related quality of life (HRQOL) of patients with insulin - t reated diabetes and symptoms of diabetic gastro p a resis and to assess the impact of domperidone on HRQOL in these patients
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Allergic and immunologic disorders of the eye. Part II: Ocular allergy
Allergy affects more than 15% of the world population, and some studies have shown that up 30% of the US population has some form of allergy. Most of these patients have various target organs for their allergies, and most have ocular involvement.
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Efficacy and safety of etoricoxib 30 mg and celecoxib 200 mg in the treatment…
To compare the efficacy of etoricoxib 30 mg with the generally maximum recommended dose of celecoxib, 200 mg, in the treatment of steoarthritis (OA) in two identically designed studies
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Postoperative Etoricoxib versus Ketoprofen Administration for Pain Management…
This randomized double-blind study compared the analgesic efficacy and tolerability of etoricoxib versus ketoprofen in 165 patients with elective total primary knee arthroplasty
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Adapalene: A Review of its Use in the Treatment of Acne Vulgaris
Adapalene (Differin) is a retinoid agent indicated for the topical treatment of acne vulgaris. In clinical trials, 0.1% adapalene gel has proved to be effective in this indication and was as effective as 0.025% tretinoin gel, 0.1% tretinoin microsphere gel, 0.05% tretinoin cream and 0.1% tazarotene gel once every two days; however, the drug was less effective than once-daily 0.1% tazarotene …
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Adapalene gel 0.3% for the treatment of acne vulgaris: A multicenter, randomi…
Adapalene gel 0.3% was significantly superior to adapalene gel 0.1% and vehicle in success rate, total lesion count, and inflammatory lesion count. A consistent, dose-dependent effect was demonstrated for all efficacy measures. Signs and symptoms were mostly mild to moderate and transient in nature.
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