New G-CSF agonists for neutropenia therapy

Granulocyte colony-stimulating factor (G-CSF; filgrastim) and its pegylated form (pegfilgrastim) are widely used to treat neutropenia associated with myelosuppressive chemotherapy and bone marrow transplantation, AIDS-associated or drug-induced neutropenia, and neutropenic diseases. G-CSF facilitates restoration of neutrophil counts, decreases incidence of infection/febrile neutropenia and redu…

The immunology of asthma

Asthma is a common disease that affects 300 million people worldwide. Given the large number of eosinophils in the airways of people with mild asthma, and verified by data from murine models, asthma was long considered the hallmark T helper type 2 (TH2) disease of the airways. It is now known that some asthmatic inflammation is neutrophilic, controlled by the TH17 subset of helper T cells, and…

Comparison of the Efficacy of Tenofovir Versus Tenofovir plus Entecavir in th…

Edition

-

ISBN/ISSN

-

Collation

-

Series Title

-

Call Number

-

Left Ventricular Hypertrophy by the Surface ECG

Left ventricular hypertrophy (LVH) is defined as an increase in left ventricular mass (LVM) associated with structural changes of myocardium. The increase in LVM and associated changes are associated with changes in depolarization and repolarization, manifested as a variety of altered QRS and T patterns. Increased QRS voltage has been considered to be a specific ECG finding in LVH, and ECG crit…

Acute coronary syndromes in women and men

Evidence of sex-related disparities in the care and outcomes of patients with acute coronary syndrome (ACS) emerged >30 years ago, and yet the mechanisms behind these sex-specific differences remain unclear. In this Review, we discuss the current literature on differences between women and men in the clinical presentation, pathophysiology, evaluation, management, and outcomes of ACS. Although …

Diagnosis of Hepatic Nodules in Patients at Risk for Q1 Hepatocellular Carcin…

Unequivocal diagnosis with avoidance of false- positive results is very relevant in patients with liver disease in whom an imaging technique detects a nodule that raises the potential emergence of hepatocellular carcinoma (HCC). Although biopsy confirmation is standard in most cancers, several studies have shown that reliable HCC diagnosis may be established by imaging techniques in patient…

Pathogenesis of Gastric Cancer

Gastric cancer (GC) is the fifth most common malignancy and the third leading cause of cancer-related death worldwide. GC is a heterogeneous disease and the endpoint of a long multistep process largely influenced by Helicobacter pylori infection, genetic susceptibility, and environmental factors. In a subset of GC cases, infection with the Epstein–Barr virus (EBV) may also be involved. The d…

The Pathogenesis of Lupus Nephritis

Lupus nephritis is an immune complex GN that develops as a frequent complication of SLE. The pathogenesis of lupus nephritis involves a variety of pathogenic mechanisms. The extrarenal etiology of systemic lupus is based on multiple combinations of genetic variants that compromise those mechanisms normally assuring immune tolerance to nuclear autoantigens. This loss of tolerance becomes clinica…

Etiology of Peptic Ulcer Disease

Peptic ulcer (PU) is defect in the gastrointestinal mucosa usually located in the stomach and duodenum, but it can develop in any portion of the gastrointestinal tract that is exposed to acid and pepsin in sufficient concentration and duration. Histologically, ulcers are defined as necrotic mucosal defects that extend through the muscularis mucosa and into submucosa, whereas superficial necrot…

Evidence-based clinical practice guidelines for peptic ulcer disease 2015

The Japanese Society of Gastroenterology (JSGE) revised the evidence-based clinical practice guidelines for peptic ulcer disease in 2014 and has created an English version. The revised guidelines consist of seven items: bleeding gastric and duodenal ulcers, Helicobacter pylori (H. pylori) eradication therapy, non-eradication therapy, drug-induced ulcer, non-H. pylori, non-nonsteroidal anti-inf…