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Inhalational Anaesthesia Versus Total Intravenous Anaesthesia During a Rigid …
General anaesthesia is routinely used for rigid bronchoscopy in paediatrics for different causes. Both methods of anaesthesia were used inhalational and total intravenous anaesthesia (TIVA
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Remifentanil-based total intravenous anesthesia for pediatric rigid bronchosc…
Laryngoscopy and stimuli inside the trachea cause an intense sympatho-adrenal response. Remifentanil seems to be the optimal opioid for rigid bronchoscopy due to its potent and short-acting properties. The purpose of this study was to compare bolus propofol and ketamine as an adjuvant to remifentanil-based total intravenous anesthesia for pediatric rigid bronchoscopy
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An update on dry eye disease molecular treatment: advances in drug pipelines
Dry eye disease is a common disorder provoking changes in tear film and ocular surface. Untreated dry eye could cause ocular infections, corneal ulcer and blindness. Only a few drugs are authorized so far for the treatment of dry eye disease and the possibilities of evolution in this sector are immense. Consequently, a significant number of new potential solutions are under development or place…
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Action on diabetic macular oedema: achieving optimal patient management in tr…
Diabetes has been estimated to affect over 8% of the world’s population and, as a significant cause of mortality and major morbidity, is now posing one of the greatest challenges for our healthcare systems. The global prevalence of diabetes is set to double over the next 20 years, with the vast majority of this increase related to type 2 diabetes. As such, type 2 diabetes is increasingly rec…
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Update in Current Diagnostics and Therapeutics of Dry Eye Disease
Dry eye disease (DED) represents a heterogeneous group of conditions with tear film insufficiency and signs and/or symptoms of ocular surface irritation. The clinical manifestations of DED can be highly variable; hence the diagnosis is often based on a combination of symptoms, signs, and clinical tests, given that any one of these alone would miss a significant number of patients. Similarly, th…
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Pedoman Pencegahan Dan Pengendalian Coronavirus Disease (Covid-19)
Coronavirus adalah keluarga besar virus yang menyebabkan penyakit mulai dari gejala ringan sampai berat. Ada setidaknya dua jenis coronavirus yang diketahui menyebabkan penyakit yang dapat menimbulkan gejala berat seperti Middle East Respiratory Syndrome (MERS) dan Severe Acute Respiratory Syndrome (SARS). Coronavirus Disease 2019 (COVID-19) adalah penyakit jenis baru yang belum pernah diidenti…
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Research Priorities for Endometriosis: Recommendations From a Global Consorti…
The 3rd International Consensus Workshop on Research Priorities in Endometriosis was held in Sa˜o Paulo on May 4, 2014, following the 12th World Congress on Endometriosis. The workshop was attended by 60 participants from 19 countries and was divided into 5 main sessions covering pathogenesis/pathophysiology, symptoms, diagnosis/classification/prognosis, disease/ symptom management, and res…
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Coronavirus Disease 2019–COVID-19
In recent decades, several new diseases have emerged in different geographical areas, with pathogens including Ebola virus, Zika virus, Nipah virus, and coronaviruses (CoVs). Recently, a new type of viral infection emerged in Wuhan City, China, and initial genomic sequencing data of this virus do not match with previously sequenced CoVs, suggesting a novel CoV strain (2019-nCoV), which has now …
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A Guide to Non-Alcoholic Fatty Liver Disease in Childhood and Adolescence
Non-Alcoholic Fatty Liver Disease (NAFLD) is now the most prevalent form of chronic liver disease, affecting 10%–20% of the general paediatric population. Within the next 10 years it is expected to become the leading cause of liver pathology, liver failure and indication for liver transplantation in childhood and adolescence in the Western world. While our understanding of the pathophysiologi…
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Clinical assessment and management of liver fibrosis in nonalcoholic fatty li…
Non-alcoholic fatty liver disease (NAFLD) is among the most frequent etiologies of cirrhosis worldwide, and it is associated with features of metabolic syndrome; the key factor influencing its prognosis is the progression of liver fibrosis. This review aimed to propose a practical and stepwise approach to the evaluation and management of liver fibrosis in patients with NAFLD, analyzing the curr…
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