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Standardized bioactive fraction of Phaleria macrocarpa (Proliverenol) prevent…
The data support our hypothesis that Proliverenol has a potential ability in protecting cells from ethanol-induced hepatotoxicity. We propose that Proliverenol provides hepatoprotective activity through up-regulating expression of APEX1 that repress DNA fragmentation, and down-regulating expression of nuclear factor-kB, tumor necrosis factora and caspase-8, which therefore repress ALT leakage a…
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Fraksi Bioaktif dan Inovasi Terapeutik: Jembatan Etnofarmasi dan Sains Modern
Studi fraksi bioaktif telah muncul sebagai bidang transformatif dalam farmakologi modern, menekankan pemurnian dan isolasi senyawa yang dipandu bioassay dengan potensi terapeutik.1,2,3 Makalah ini mengeksplorasi mekanisme, metodologi, dan implikasi fraksi bioaktif dalam memajukan penemuan obat. Mengambil pengetahuan etnofarmakologi, makalah ini menyoroti integrasi k…
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The Effect of Phaleria macrocarpa Bioactive Fraction (Proliverenol) Supplemen…
Liver is considered one of the most vital organs, acting as the center of metabolism of nutrients and excretion of waste products. Non-alcoholic fatty liver disease (NAFLD) is one of the main causes of chronic liver disease. The management of NAFLD continues to evolve, and clinicians are currently faced with a variety of alternative options, both non-pharmac…
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