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Bioequivalence study of two clopidogrel film-coated tablet formulations in he…
The present study was performed to compare the bioavailability of two clopidogrel 75 mg film-coated tablet formulations (test formulation and reference formulation). This study was a randomized, single-blind, two-period, two-sequence cross-over study which included 24 healthy adult male and female subjects under fasting condition. The pharmacokinetic parameters were assessed based on the concen…
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Clopidogrel Use and Long-term Clinical Outcomes After Drug-Eluting Stent Impl…
An observational study examining consecutive patients receiving intracoronary stents at Duke Heart Center, a tertiary care medical center in Durham, NC, between January 1, 2000, and July 31, 2005, with follow-up contact at 6, 12, and 24 months through September 7, 2006. Study population included 4666 patients undergoing initial percutaneous coronary intervention with BMS (n=3165) or DES (n=1501…
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Clopidogrel in non-ST-segment elevation acute coronary syndromes
Platelets play a central role in the pathophysiology of arterial thrombosis in patients with acute coronary syndrome (ACS). Aspirin is superior to placebo in preventing mortality and ischemic events in patients with ACS. Clopidogrel, when added to aspirin and given daily for up to 1 year, reduces cardiovascular death, myocardial infarction and stroke by 20% in patients presenting with ACS. The…
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Platelet Response to Clopidogrel Is Attenuated in Diabetic Patients Undergoin…
Type 2 diabetes is accompanied by platelet function disorders leading to an accelerated process of atherosclerosis and increased risk for atherothrombotic complications (1–4). Previous data (5,6) suggest a worse outcome for diabetic patients after acute coronary events. Recently, a high variability of response to clopidogrel measured by platelet function tests has been reported (7) amon…
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Efficacy and safety of ticagrelor versus clopidogrel in acute coronary syndro…
Ticagrelor treatment could provide a marginally favorable effect at the expense of an increased risk of dyspnea n real-life situations. This pilot study provides a scientific basis to call for a larger, suitably powered Phase 4 prospective or observational study in this ethnic population.
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Challenges in the management of older patients with acute coronary syndromes …
Ischaemic heart disease (IHD), in particular acute coronary syndrome (ACS), comprising ST-elevation myocardial infarction, non-ST- elevation myocardial infarction and unstable angina, is the leading cause of death worldwide. Age is a major predictor of adverse outcome following ACS
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Cardiovascular Implications of the COVID-19 Pandemic: A Global Perspective
The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), represents the pandemic of the century, with approximately 3.5 million cases and 250,000 deaths worldwide as of May 2020. Although respiratory symptoms usually dominate the clinical presentation, COVID-19 is now known to also have potentially serious cardiovascular consequences, in…
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ESC Guidance for the Diagnosis and Management of CV Disease during the COVID-…
The SARS-CoV-2 causing COVID-19 has reached pandemic levels since March 2020. In the absence of vaccines or curative medical treatment, COVID-19 exerts an unprecedented global impact on public health and health care delivery. Owing to the unexpected need for large capacities of intensive care unit (ICU) beds with the ability to provide respiratory support and mechanical ventilation, temporary r…
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Antiplatelet Therapy in Ischemic Stroke and Transient Ischemic Attack An Over…
Stroke is a leading cause of mortality and disability worldwide. Initial manifestations of acute cerebral ischemia, such as ischemic stroke and transient ischemic attack (TIA), are often followed by recurrent vascular events, including recurrent stroke. To reduce this burden, antiplatelet therapy is a key component of the management of noncardioembolic ischemic stroke and TIA.
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Health Care Guideline: Diagnosis and Initial Treatment of Ischemic Stroke
Stroke is the fifth leading cause of death in the United States and a leading cause of serious long-term disability (Mozzafarian, 2015; Kochanek, 2014). Annually, approximately 800,000 people in the United States have a stroke, and 130,000 die (Centers for Disease Control and Prevention, 2016). Of all strokes, 87% are ischemic strokes (Mozaffarian, 2015). In Minnesota, ischemic stroke death rat…
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