Unblinded studies suggested that sucralfate prophylaxis for stress is associated with a lower rate of nosocomial pneumonia than acid-reducing approaches. We performed a randomized, double blind, double-sham clinical trial comparing the exact microbial effects of each treatment
Critically ill patients who require mechanical ventilation are at increased risk for gastrointestinal bleeding from stress ulcers. There are conflicting data on the effect of histamine H2-receptor antagonists and the cytoprotective agent sucralfate on rates of gastrointestinal bleeding, ventilator-associated pneumonia, and mortality
Peptic ulcer is an acid related disorder of gastrointestinal tract. Gastritis, erosions, and peptic ulcer of the upper astrointestinal (GI) tract require gastric acid for their formation. Peptic Ulcer Disease differs from gastritis and erosions in those ulcers typically extend deeper into the muscularis mucosa. There are three common forms of peptic ulcers, Helicobacter pylori associated, non-…
The Japanese Society of Gastroenterology (JSGE) revised the evidence-based clinical practice guidelines for peptic ulcer disease in 2014 and has created an English version. The revised guidelines consist of seven items: bleeding gastric and duodenal ulcers, Helicobacter pylori (H. pylori) eradication therapy, non-eradication therapy, drug-induced ulcer, non-H. pylori, non-nonsteroidal anti-infl…