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Pharmacokinetic analysis of the time course of effect of atracurium
To examine the ability to determine clinically important pharmacokinetic and pharmacody namic parameters of atracurium by the analysis of the time course of effect without the use of plasma concentration data.
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Rapid tracheal intubation with atracurium: the timing principle
The "Timing Principle" utilises a single bolus of nondepolarising neuromuscular blocking drug followed by thiopentone given at the onset of clinical weakness. The purpose of this study was to compare the intubating conditions after succinylcholine and after atracurium used according to the "timing principle." Eighty patients were randomly assigned to four groups of 20.
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Use of the muscle relaxant atracurium in anephric patients: preliminary commu…
Atracurium is a new, non-depolarizing muscle relaxant which rapidly breaks down in vivo and appears to require neither renal nor hepatic function for its elimination. As the commonly used non-depolarizing muscle relaxants carry the risk of prolonged effect when used in anephric patients, atracurium appears to have special promise in this situation. A preliminary account of the successful use of…
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Experts’ guidelines of intubation and extubation of the ICU patient of Fren…
Intubation and extubation of ventilated patients are not risk-free procedures in the intensive care unit (ICU) and can be associated with morbidity and mortality. Intubation in the ICU is frequently required in emergency situations for patients with an unstable cardiovascular or respiratory system. Under these circumstances, it is a highrisk procedure with life-threatening complications (20–5…
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Drugs of anaesthesia and cancer
Anaesthesia represents one of the most important medical advances in history,and,nowadays, can widely beconsidered safe,thanks to the discovery of new drugs and the adoption of modern technologies .Nevertheless,anaesthetic practices still represent cause for concern regarding the consequence sthey produce. Various anaesthetics are frequently used without knowing their effects on specific diseas…
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Downward trend in pediatric resident laryngoscopy participation in pediatric …
As of July 2013, pediatric resident trainee guidelines in the United States (US) no longer require proficiency in non-neonatal tracheal intubation (TI). We hypothesized that laryngoscopy by pediatric residents has decreased over time, with a more pronounced decrease after this guideline change.
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