In a prospective cross-sectional analysis, we compared endogenous fibrinolysis in NVAF patients (n = 180) taking aspirin, warfarin, or apixaban. In a prospective longitudinal study, patients were tested before and after apixaban (n = 80). Endogenous fibrinolysis was assessed using the Global Thrombosis Test (GTT) and thromboelastography (TEG). Endogenous fibrinolysis [measured by GTT lysis time…
Abstract: Deep vein thrombosis (DVT) refers to the formation of thrombosis within the deep veins, dominantly occurring in the pelvis or lower limbs. This clinical syndrome has gained attention as one complication of DVT, pulmonary embolization, can be fatal. Therefore, early detection and systematic management of DVT and related complica tions are essential in clinical practice. As the clinica…
Clopidogrel (Plavix®, Iscover®) selectively and irreversibly inhibits adenosine diphosphate (ADP)-induced platelet aggregation. Long-term administration of clopidogrel was associated with a modest but statistically significant advantage over aspirin in reducing adverse cardiovascular outcomes in patients with established cardiovascular disease in the CAPRIE trial. In other large well designed…
Clopidogrel is an ADP receptor antagonist that is indicated for the reduction of atherosclerotic events including myocardial infarction, ischaemic stroke and vascular death in patients with atherosclerosis manifested by recent stroke, myocardial infarction or established peripheral vascular disease
Deep vein thrombosis (DVT) adalah bekuan darah di vena dalam yang sebagian besar tersusun atas fibrin, sel darah merah, serta sebagian kecil komponen leukosit dan trombosit. Diagnosis DVT ditegakkan berdasarkan gejala klinis dan pemeriksaan penunjang berupa laboratorium dan radiologi. Penatalaksanaan DVT dapat berupa terapi non-farmakologis, farmakologis, ataupun pembedahan
The current standard initial therapies for deep venous thrombosis are low-molecular-weight heparin and unfractionated heparin. In a dose-ranging study of patients with symptomatic deep venous thrombosis, fondaparinux had efficacy and a safety profile similar to those of low-molecular-weight heparin (dalteparin)