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The Impact of Atorvastatin Treatment on the Distribution of Low-Density Lipop…
Clinical trial results indicate that statin therapy aimed at normalising the lipid profile can prevent and reduce the risk of cardiovascular events. Both LDL and HDL consist of several subfractions, with only the smallest and densest subfractions being the most atherogenic. We examine the effect of Atorvastatin treatment not only on basic lipid profile parameters but also atherogenic lipoprotei…
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Atorvastatin-Associated Gynecomastia
Clinicians should be aware of the risk of statin-associated gynecomastia.
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Comparison of Efficacy of Atorvastatin and Rosuvastatin in Patients With Acut…
Acute coronary syndrome (ACS) remains a leading cause of morbidity and mortality worldwide. Statins, particularly atorvastatin, and rosuvastatin, are crucial in managing cholesterol levels and reducing cardiovascular risk in ACS patients. However, direct comparative studies between these two statins are limited. This meta-analysis aimed to compare the efficacy of atorvastatin and rosuvastatin i…
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Atherosclerotic Cardiovascular Disease and Heart Failure in Type 2 Diabetes â…
Cardiovascular disease remains the principal cause of death and disability among patients with diabetes mellitus. Diabetes exacerbates mechanisms underlying atherosclerosis and heart failure. Unfortunately, these mechanisms are not adequately modulated by therapeutic strategies focusing solely on optimal glycemic control with currently available drugs or approaches. In the setting of multi-fact…
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Efficacy and safety of statin therapy in older people: a meta-analysis of ind…
Statin therapy has been shown to reduce major vascular events and vascular mortality in a wide range ofrnindividuals, but there is uncertainty about its efficacy and safety among older people. We undertook a meta-analysisrnof data from all large statin trials to compare the effects of statin therapy at different ages.
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Statin Treatment in Patients With Intracerebral Hemorrhage
Ever since the publication of the SPARCL trial (Stroke Prevention by Aggressive Reduction in Cholesterol Levels) in 2006, neurologists became aware of the fact that statins may increase the risk for future intracerebral hemorrhage (ICH) in patients with previous ischemic stroke or ICH.1,2 At the same time, observational studies reported an increased risk for hemorrhagic transformation or even…
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Pleiotropic Effects of Statins on the Cardiovascular System
The statins have been used for 30 years to prevent coronary artery disease and stroke. Their primary mechanism of action is the lowering of serum cholesterol through inhibiting hepatic cholesterol biosynthesis thereby upregulating the hepatic low-density lipoprotein (LDL) receptors and increasing the clearance of LDLcholesterol. Statins may exert cardiovascular protective effects that are in…
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Statins in nonsurgical and surgical periodontal therapy. A systematic review …
The cholesterol-lowering drugs, statins, possess anti-inflammatory, antimicrobial and pro-osteogenic properties, and thus have been tested as an adjunct to periodontal treatment. The present systematic review aimed to answer the following focused research question: What is the effect of local and/or systemic statin use on periodontal tissues in preclinical in vivo studies of experimentally indu…
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Metabolic syndrome update
The metabolicsyndromeisamultiplexriskfactorforatheroscleroticcardiovasculardiseaseandtype2diabetes.Itiscomposed of atherogenicdyslipidemia,elevatedbloodpressure,insulinresistanceandelevatedglucose,apro-thromboticstate,anda pro-inflammatorystate.Excessenergyintakeandconcomitantobesityarethemajordriversofthesyndrome.Lifestyle intervention canreversemetabolicriskfactors,butattimes,drugtherapies…
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Metabolic syndrome : Pathophysiology, Management, and Modulation by Natural C…
Metabolic syndrome (MetS) represents a cluster of metabolic abnormalities that include hypertension, central obesity, insulin resistance, and atherogenic dyslipidemia, and is strongly associated with an increased risk for developing diabetes and atherosclerotic and nonatherosclerotic cardiovascular disease (CVD). The pathogenesis of MetS involves both genetic and acquired factors that contribut…
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