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The colon-selective spasmolytic otilonium bromide inhibits muscarinic M3 rece…
Otilonium bromide (OB) is a smooth muscle relaxant used in the treatment of irritable bowel syndrome. Otilonium bromide has been shown to interfere with the mobilization of calcium in intestinal smooth muscle, but the effects on other intestinal tissues have not been investigated. We identifed the muscarinic receptor subtype coupled to calcium signals in colonic crypt derived from the human c…
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A DISTRIBUTION STUDY WITH 14C-OTILONIUM BROMIDE IN THE RAT: EVIDENCE FOR SELE…
The aim of this study was to determine the plasma levels and the tissue distribution of otilonium bromide, measured as total radioactivity, after oral administration of 2 mg/kg of 14C-labeled drug to rats. Radioactivity levels were very low in the plasma (ranging from 2.7 ng Eq/ml at 1.5 h to 0.6 ng Eq/ml at 24 h) as compared with those found in the gastrointestinal (GI) tract, indicating negli…
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Otilonium bromide enhances sensory thresholds of volume and pressure in patie…
Visceral hyperalgesia has been suggested to play a role in the development of symptoms presented by irritable bowel syndrome patients. Otilonium bromide was developed to block smooth muscle Ca release to control crampingpain of these patients. Aims: to determine whether otilonium bromide can influence sensory thresholds of patients sufferingfrom irritable bowel syndrome.
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