Ankylosing spondylitis, chronic fatigue and depression improved after stromal…

Osteoarthritis is a prevalent chronic disease that impacts quality of life and imposes a heavy economic burden. Despite this there is no confirmed treatment that could prevent progressive destruction of osteoarthritic joints. Mesenchymal stem cells with their regenerative and immunosuppressive properties have emerged as a potential therapy

Exercise programmes for ankylosing spondylitis (Review)

Exercise programmes are oPen recommended for managing ankylosing spondylitis (AS), to reduce pain and improve or maintain functional capacity

The genetic basis of ankylosing spondylitis: new insights into disease pathog…

Ankylosing spondylitis (AS) is a complex disease involving multiple risk factors, both genetic and environmental. AS patients are predominantly young men, and the disease is characterized by inflammation and ankylosis, mainly at the cartilage–bone interface and enthesis. HLA-B27 has been known to be the major AS-susceptibility gene for more than 40 years. Despite advances made in the past few…

Clinical Outcomes of Patients with Rheumatoid Arthritis Treated in a Disease …

Care models can affect the clinical outcome of patients with rheumatic and musculoskeletal diseases

Psoriatic Arthritis

Psoriasis is a common skin disease that is associated with multiple coexisting conditions. The most prevalent coexisting condition, psoriatic arthritis, develops in up to 30% of patients with psoriasis and is characterized by diverse clinical features, often resulting in delayed diagnosis and treatment. Initial reports emphasized a benign course in most patients, but it is now recognized that p…

The Pathogenesis of Rheumatoid Arthritis

Rheumatoid arthritis is a common autoimmune disease that is associated with progressive disability, systemic complications, early death, and socioeconomic costs.1 The cause of rheumatoid arthritis is unknown, and the prognosis is guarded. However, advances in understanding the pathogenesis of the disease have fostered the development of new therapeutics, with improved outcomes. The current trea…

Knee osteoarthritis: pathophysiology and current treatment modalities

For decades, multiple attempts to fully understand knee osteoarthritis pathophysiology and natural history have been attempted. Despite the extensive amount of research regarding this topic, there are still marked controversies. This multifactorial condition gets influenced by local, systemic, and external factors and its progression and/or response to treatments widely varies from patient to p…

COMPARATIVE EFFICACY OF LOW- AND HIGHMOLECULAR WEIGHT INTRA-ARTICULAR HYALURO…

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Viscosupplementation for the treatment of osteoarthritis of the knee

To assess the effects of viscosupplementation in the treatment of OA of the knee. The products were hyaluronan and hylan derivativesrn(Adant, Arthrum H, Artz (Artzal, Supartz), BioHy (Arthrease, Euflexxa, Nuflexxa), Durolane, Fermathron, Go-On, Hyalgan, HylanrnG-F 20 (Synvisc Hylan G-F 20), Hyruan, NRD-101 (Suvenyl), Orthovisc, Ostenil, Replasyn, SLM-10, Suplasyn, Synject and Zeelrncompositum).

The role of intra-articular hyaluronan (Sinovial) in the treatment of osteoar…

Osteoarthritis (OA) leads to significant pain and disability. For pain relief, a tailored approach using non-pharmacological and pharmacological therapies is recommended. If adequate symptom relief is not achieved with acetaminophen, other pharmacological options include non-steroidal anti-inflammatory drugs (NSAIDs), topical analgesics, intra-articular corticosteroids and intraarticular hyalur…