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SERPINA1 Gene Variants in Granulomatosis with Polyangiitis
Alpha-1 antitrypsin (A1AT) deficiency is one of the most common genetic disorders in Caucasian population. There is a link between granulomatosis with polyangiitis (GPA) and most frequent variants of SERPINA1 gene encoding severe alpha-1 antitripsin deficiency
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A Comparative Tolerance Study of Terfenadine - Pseudoephedrine Combination Ta…
In this multicentre , double-blind, randomized, parallel group study, 315 patients with allergic or vasomotor rhinitis were treated on a twice daily dosing schedule with either a 60 mg terfenadine -120 mg pseudoephedrine hydrochloride combination or 120 mg pseudoephedrine hydrochloride (extended release) for 2 weeks. Noclinically significant differences between the two groups were noted in body…
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Effects of terfenadine and pseudoephedrine, alone and in combination in a nas…
The effects of terfenadine and pseudoephedrine, alone and in combination, have been assessed in a nasal provocation test and in perennial rhinitis.
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SERPINA1 and MAN1B1 polymorphisms are not linked to severe liver disease in a…
Fifteen to twenty percent of alpha-1 antitrypsin deficiency patients (A1ATD) have a severe liver outcome (portal hypertension -PHT) during childhood. Since they all share the same ZZ SERPINA1 genotype and that environmental factors such as alcohol cannot be advanced, the presence of modifier genes is now well recognized. SNPs located on the SERPINA1 and MAN1B1 genes have already been tes…
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