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Recent advances in the management of radiation colitis
Radiation colitis, an insidious, progressive disease of increasing frequency, develops 6 mo to 5 years after regional radiotherapy for malignancy, owing to the deleterious effects of the latter on the colon and the small intestine. When dealing with radiation colitis and its complications, the most conservative modality should be employed because the areas of intestinal injury do not tend to h…
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EULAR recommendations for the management of rheumatoid arthritis with synthet…
In this article, the 2010 European League against Rheumatism (EULAR) recommendations for the management of rheumatoid arthritis (RA) with synthetic and biological disease-modifying antirheumatic drugs (sDMARDs and bDMARDs, respectively) have been updated. The 2013 update has been developed by an international task force, which based its decisions mostly on evidence from three systematic litera…
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Treating rheumatoid arthritis to target: 2014 update of the recommendations o…
Reaching the therapeutic target of remission or low-disease activity has improved outcomes in patients with rheumatoid arthritis (RA) significantly. The treat-to-target recommendations, formulated in 2010, have provided a basis for implementation of a strategic approach towards this therapeutic goal in routine clinical practice, but these recommendations need to be re-evaluated for appropriaten…
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Inflammation beyond the Joints: Rheumatoid Arthritis and Cardiovascular Disease
Rheumatoid Arthritis (RA), a chronic systemic inflammatory disease which affects approximately 1% of the population, is classically characterized by inflammation and synovitis that leads to cartilage damage and juxta-articular bone destruction. Accumulating evidence indicates that a major cause of death among RA patients is Cardio Vascular Disease (CVD), in excess of that in the general population
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Patient Diagnosis Resource for Radiation Colitis
Your doctor has determined that you have radiation colitis, an inflammation of the colon that occurs as a side effect of cancer radiation therapy to the abdomen or pelvis. The condition can arise from external radiation treatment delivered by a high energy X-ray machine or internal radiation therapy, which is delivered through small implants placed directly into or near the cancerous tumor
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Laryngeal framework surgery: current strategies
Laryngeal framework surgery (LFS) is an indispensable surgical approach for the treatment of voice problems. The purpose of this review is to single out some relevant articles published on the topic of LFS from 2015 to mid-2016. Articles referring to injection laryngoplasty (augmentation) are entirely left aside
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PREFILLED SYRINGES: INNOVATIONS THAT MEET THE GROWING DEMAND
The use of prefilled syringes is a modern way to apply parenteral drugs. With the achievements in science and technology in the past twenty years an increasing number of injectables apply prefilled syringes. The benefits compared with vial-disposable syringe concepts are obviously convenience and ease of handling as well as advantages in safety and a reduction of drug overfill
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Developments in the packaging of pre-filled syringes
The pre-filled syringe is an increasingly attractive presentation for both new and established parenteral pharmaceuticals and vaccines. In this article, the author explores how innovative carton packaging solutions can enhance this presentation whilst meeting the stringent requirements of both product protection and environmental sustainability. He analyses recent developments in the packaging …
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Ketorolac: a review of its pharmacodynamic and pharmacokinetic properties and…
Ketorolac is a non-steroidal agent with potent analgesic and moderate antiinflammatory activity. It is administered as the tromethamine salt orally, intramuscularly, intravenously, and as a topical ophthalmic solution. Clinical studies indicate single-dose efficacy greater than that of morphine, pethidine (meperidine) and pentazocine in moderate to severe postoperative pain, with some evidence …
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Ketorolac tromethamine as compared with morphine sulfate for treatment of pos…
Ketorolac tromethamine, a nonnarcotic, prostaglandin synthesisinhibiting analgesic, was compared with morphine sulfate for relief of moderate to severe postoperative pain. The 155 patient participants received single intramuscular doses of either ketorolac, 10, 30, or 90 mg, or morphine, 6 or 12 mg, administered in a double-blind, randomized fashion. Pain scores (verbal and visual analog) were …
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