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Efficacy and safety of rituximab combined with chemotherapy in the treatment …
The aim of this study is to systematically evaluate the safety and efficacy of rituximab plus CHOP (R-CHOP combined regimen) in patients with previously untreated diffuse large B cell lymphoma (DLBCL). Electronic database were searched for randomized-controlled studies only comparing R-CHOP to CHOP standard alone in patients with untreated DLBCL were included. The risk ratios (RRs) with their 9…
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Radiotherapy plus rituximab as first-line regimen for localized follicular ly…
Early-stage follicular lymphoma (FL) can be cured with involved-field radiotherapy (IF-RT); however, many patients relapse in non-irradiated areas. A combined association with chemotherapy could increase treatment efficacy, but toxic effects could be unacceptable. In vitro synergistic effect between rituximab (R) and RT has been observed, but clinical data are limited. We retrospectively analyz…
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Rituximab as First-Line and Maintenance Therapy for Patients With Indolent No…
To evaluate response to single-agent rituximab in patients with indolent non-Hodgkin’s lymphoma (NHL) and no previous systemic therapy, and the feasibility, toxicity, and efficacy of maintenance rituximab, administered at 6-month intervals, in patients with objective response or stable disease after first-line rituximab therapy.
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Rituximab monotherapy with eight weekly infusions for relapsed or refractory …
Information regarding rituximab monotherapy with eight weekly infusions for relapsed or refractory indolent B cell non-Hodgkin lymphoma (B-NHL), in particular for patients pretreated with rituximab, is limited. To evaluate the efficacy and safety of eight doses of rituximab monotherapy, 52 patients with relapsed or refractory indolent B-NHL were enrolled in the present study. Forty of 45 eligib…
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The Use and Effectiveness of Rituximab Maintenance in Patients with Follicula…
A total of 1439 patients completed R-based induction therapy, 1186 of whom met all inclusion criteria (541 patients received R-maintenance and 645 patients were observed). Characteristics that were found to be predictive of receiving R-maintenance were histology grade (1/2), Ann Arbor stage of disease (III/IV), geographic region (region other than the West), and practice setting (community prac…
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Diagnosis and Management of Rheumatoid Arthritis : A Review
Rheumatoid arthritis (RA) occurs in about 5 per 1000 people and can lead to severe joint damage and disability. Significant progress has been made over the past 2 decades regarding understanding of disease pathophysiology, optimal outcome measures, and effective treatment strategies, including the recognition of the importance of diagnosing and treating RA early.
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Immunotherapy in Lung Cancer
Lung cancer is the leading cause of cancer-related mortality in the United States.1 Non–small cell lung cancer (NSCLC) comprises approximately 85% of all lung cancer cases.2 Among patients with NSCLC, approximately 40% present with stage IV disease. 3 Although targeted therapy has been associated with a significant benefit in patients harboring aberrations in epidermal growth factor receptor…
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Paraneoplastic Syndromes: An Approach to Diagnosis and Treatment
Recent medical advances have improved the understanding, diagnosis, and treatment of paraneoplastic syndromes. These disorders arise from tumor secretion of hormones, peptides, or cytokines or from immune cross-reactivity between malignant and normal tissues. Paraneoplastic syndromes may affect diverse organ systems, most notably the endocrine, neurologic, dermatologic, rheumatologic, and hemat…
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Assessment of Quality of Life (QoL) in Systemic Lupus Erythematosus Patients …
One hundred sixty-four SLE patients were recruited for this study. Demographic information; clinical parameters; disease activity, as evaluated by the Systemic Lupus Erythematosus Disease Activity Index; and organ damage, as assessed by the Systemic Lupus International Collaborative Clinics/American College of Rheumatology Damage Index, were reported. Quality of life was assessed with a qualit…
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Systemic Lupus Erythematosus : Epidemiology, Pathophysiology, Manifestations,…
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder, characterized by production of autoantibodies directed against nuclear and cytoplasmic antigens, which may affect several different organs, with a plethora of different clinical and immunologic abnormalities, characterized by a relapsing and remitting clinical course
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