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Comparative nasal airflow with loratadine-pseudoephedrine and fluticasone nas…
Although it is known that oral antihistamine-pseudoephedrine combination tablets have a faster onset than intranasal corticosteroid sprays in the treatment of allergic rhinitis after the first dose, the magnitude of change has not been measured in a comparative manner. Furthermore, the sensation of sprayed liquid in the nose may lead patients to mistakenly believe that intranasal steroid sprays…
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Preparation of delayed-release multiparticulate formulations of diclofenac so…
Diclofenac sodium was used as a model drug for preparation of delayed-release (DR) multiparticulates, which were further processed into solid oral dosage forms such as capsules and tablets. Multiple unit pellets systems (MUPS) were prepared from different types of starter pellets (inert cores) including microcrystalline cellulose pellets, sugar spheres, isomalt pellets and novel calcium phospha…
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Oral Modified Release Multiple-Unit Particulate Systems: Compressed Pellets, …
Oral modified-release multiparticulate dosage forms, which are also referred to as oral multiple-unit particulate systems, are becoming increasingly popular for oral drug delivery applications. The compaction of polymer-coated multiparticulates into tablets to produce a sustained-release dosage form is preferred over hard gelatin capsules. Moreover, multiparticulate tablets are a promising solu…
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BSACI guideline for the diagnosis and management of allergic and non-allergic…
This is an updated guideline for the diagnosis and management of allergic and non-allergic rhinitis, first published in 2007. It was produced by the Standards of CareCommittee of the British Society of Allergy and Clinical Immunology, using accre-dited methods. Allergic rhinitis is common and affects 10–15% of children and 26%of adults in the UK, it affects quality of life, school and work at…
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Efficacy and safety of loratadine plus pseudoephedrine in patients with seaso…
Antihistamines have been shown to have a varietyrnof therapeutic effects in asthma. Although nasal obstructionrnmay play an important role in modulating lower airwayrnfunction, no prior trial has used a decongestant in combinationrnwith an antihistamine in patients with allergic rhinitisrnand concomitant asthma.
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The efficacy of Rhinos® SR on nasal resistance and nasal symptoms in patient…
Rhinos® SR is a fixed combination of 5 mg loratadine and 60 mg pseudoephedrine immediate release and 60 mg pseudoephedrine sustained release. The present study was aimed to assess the efficacy of Rhinos® SR on nasal airway resistance (NAR) objectively using rhinomanometer and on nasal symptoms in patients with perennial allergic rhinitis (PAR) in a tropical country. This was a randomized, dou…
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Teknologi Sediaan Farmasi : Sustained-Release Oral
Penanganan penyakit menggunakan obat (drug treatment) merupakan bentuk terapi yang paling umum digunakan. Therapeutic efficacy obat dalam penggunaan klinis tidak hanya tergantung dari intrinsic pharmacologic activity bahan aktifnya, melainkan juga ditentukan oleh interaksi molekul obat dengan berbagai kondisi selama perjalanannya dari tempat pemberian menuju tempat kerjanya
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Efficacy of Loratadine Compared with Fexofenadine or Placebo for the Treatmen…
Compared with placebo, both loratadine and fexofenadine provided significant relief of the symptoms of SAR. At the first assessment following the first dose, however, loratadine demonstrated a significant reduction from baseline in TSS compared with fexofenadine. In addition, time-to-event analysis indicated that the reduction in symptoms occurred significantly earlier with loratadine
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Allergic rhinitis and asthma: How important is the link?
Dysfunction of the upper and lower airways frequently coexist, and they appear to share key elements of pathogenesis. Data from epidemiologic studies indicate that nasal symptoms are experienced by as many as 78% of patients with asthma and that asthma is experienced by as many as 38% of patients with allergic rhinitis. Studies also have identified a temporal relation between the onset of rh…
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Antihistamines General Statement
Antihistamines, which inhibit the effects of histamine at H1 receptors, have been classified as first generation (i.e., relatively sedating) or second generation (i.e., relatively nonsedating).
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