Advances in rectal drug delivery systems

Drug delivery via the rectum is a useful alternative route of administration to the oral route for patients who cannot swallow. Traditional rectal dosage forms have been historically used for localized treatments including delivery of laxatives, treatment of hemorrhoids and for delivery of antipyretics. However, the recent trend is showing an increase in the development of novel rectal deliver…

Ketorolac, diclofenac and ketoprofen are equally safe for pain relief after m…

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Ketoprofen Pharmacokinetics, Efficacy, and Tolerability in Pediatric Patients

The NSAID ketoprofen is used widely in the management of inflammatory and musculoskeletal conditions, pain, and fever in children and adults. Pharmacokinetic studies show that drug exposure after a single intravenous dose is similar in children and adults (after dose normalization), and thus similar mg /kg bodyweight dosing may be used in children and adults. Ketoprofen crosses the blood-bra…

Analgesic Efficacy and Pharmacokinetics of Ketoprofen Administered into a Sur…

A series of three clini cal tri als in the oral sur gery model evalu -ated the anal gesic effi cacy and phar macokinetics of keto pro - fen admin is tered locally as a strat egy for decreas ing sys temic exposure to non ster oi dal anti- inflammatory drugs (NSAIDs). A gel for mu la tion was admin istered directly into extrac tion sites 1 hour fol lowing oral sur gery, and pain inten sity wa…

Osteoarthritis

Osteoarthritis (OA) is the most common joint disorder, is associated with an increasing socioeconomic impact owing to the ageing population and mainly affects the diarthrodial joints. Primary OA results from a combination of risk factors, with increasing age and obesity being the most prominent. The concept of the pathophysiology is still evolving, from being viewed as cartilage-limited to a m…

Recent advances in the management of radiation colitis

Radiation colitis, an insidious, progressive disease of increasing frequency, develops 6 mo to 5 years after regional radiotherapy for malignancy, owing to the deleterious effects of the latter on the colon and the small intestine. When dealing with radiation colitis and its complications, the most conservative modality should be employed because the areas of intestinal injury do not tend to h…

Patient Diagnosis Resource for Radiation Colitis

Your doctor has determined that you have radiation colitis, an inflammation of the colon that occurs as a side effect of cancer radiation therapy to the abdomen or pelvis. The condition can arise from external radiation treatment delivered by a high energy X-ray machine or internal radiation therapy, which is delivered through small implants placed directly into or near the cancerous tumor

Laryngeal framework surgery: current strategies

Laryngeal framework surgery (LFS) is an indispensable surgical approach for the treatment of voice problems. The purpose of this review is to single out some relevant articles published on the topic of LFS from 2015 to mid-2016. Articles referring to injection laryngoplasty (augmentation) are entirely left aside