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Is there a link between plasma progesterone 1–2 days before frozen embryo t…
Objective: To study the efficacy of a new P preparation in aqueous solution for subcutaneous injection for inducing the predecidual transformation of the endometrium.
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A randomized trial comparing the endometrial effects of daily subcutaneous ad…
Objective: To study the efficacy of a new P preparation in aqueous solution for subcutaneous injection for inducing the predecidual transformation of the endometrium
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Luteal support after in-vitro fertilization: Crinone 8%, a sustained release …
Two progesterone presentations, a vaginal application of 90 mg progesterone per day (Crinone) or 300 mg progesterone administered orally (Utrogestan), were compared for luteal phase support of patients undergoing an in-vitro fertilization (IVF) procedure. A total of 283 patients were randomly allocated to either treatment. The treatment started within 24 h after the embryo transfer procedure an…
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Absorption of micronized progesterone from a nonliquefying vaginal cream*
An effective and convenient method to administer progesterone (P) would be useful. Injections assure reliable absorption1 but are painful. Vaginal P suppositories avoid the pain of injection and are well absorbed, but suppositories sustain P levels less effectively. Suppositories are difficult to place high in the vagina and liquefy at body temperature, which leads to substantial vaginal disc…
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PATIENTS PREFER SUBCUTANEOUS PROGESTERONE OVER VAGINAL ADMINISTRATION. UNEXPE…
OBJECTIVE: To determine if subcutaneous or transvaginal progesterone are preferred by patients after the use of both, based on the influence on their sexual life, global comfort and interference on their normal activities.
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Water soluble progesterone–hydroxypropyl-b-cyclodextrin complex for injecta…
The use of cyclodextrin to increase the water solubility of progesterone (P) was described by Pitha as a complex with b-cyclodextrin and derivates to obtain a water soluble formulation (Pitha, J.: US patent n. 4,727,064). Hydroxypropyl-b-cyclodextrin (HPBCD) has a high water solubility which allows the solubilization of high quantity of P. Considering a 1:2 guess/host complex stoichiometry it…
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