Intravenous immunoglobulin vs plasma exchange in treatment of mechanically ve…

The aim of the study is to compare efficacy of IvIg versus PE in treatment of mechanically ventilation adults with GBS in intensive care unit.

Guidelines for Prevention and Treatment of Opportunistic Infections in HIV-In…

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PRACTICE GUIDELINE FOR THE TREATMENT PATIENS WITH HIV/AIDS

Since publication in 2000 of APA’s Practice Guideline for the Treatment of Patients With HIV/ AIDS (1), new evidence has become available that affects the psychiatric care of patients with human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS). This guideline watch highlights this evidence for the following areas: epidemiology, antiretroviral medication re…

Guillain-Barré syndrome

Guillain-Barré syndrome is the most common and most severe acute paralytic neuropathy, with about 100 000 people developing the disorder every year worldwide. Under the umbrella term of Guillain-Barré syndrome are several recognisable variants with distinct clinical and pathological features. The severe, generalised manifestation of Guillain-Barré syndrome with respiratory failure aff ects 2…

Guillian-Barre syndrome as the initial presentation of systemic lupus erythem…

A number of neurological entities have been associated with systemic lupus erythematosus (SLE). Gullian-Barre syndrome (GBS) as a presenting feature of SLE remains uncommon with just 9 cases reported in the last half-century with the first case reported in 19641-9 (Table 1). We report a young female presenting with GBS in whom SLE and WHO class V lupus nephritis (LN) was subsequently diagnosed.…

Management of Guillain-Barré Syndrome

Guillain-Barré syndrome (GBS) is the most common, immune-mediated acute polyneuropathy characterized by variable degree of motor weakness, often presenting with quadriparesis. GBS with respiratory failure requiring endotracheal intubation with mechanical ventilation is common, affecting approximately 30% of patients. In addition, they present with sensory features, cranial nerve involvement, …

Systemic Lupus Erythematosus : Epidemiology, Pathophysiology, Manifestations,…

Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder, characterized by production of autoantibodies directed against nuclear and cytoplasmic antigens, which may affect several different organs, with a plethora of different clinical and immunologic abnormalities, characterized by a relapsing and remitting clinical course

Adaptive immunity

The innate immune system provides critical mechanisms for the rapid sensing and elimination of pathogens. Adaptive immunity has evolved to provide a broader and more finely tuned repertoire of recognition for both self- and nonself-antigens. Adaptive immunity involves a tightly regulated interplay between antigen-presenting cells and T and B lymphocytes, which facilitate pathogen-specific immu…

Natural Antibodies Bridge Innate and Adaptive Immunity

Natural Abs, belonging to isotypes IgM, IgG3, and IgA, were discovered nearly half a century ago. Despite knowledge about the role of the polyreactive natural IgM in pathogen elimination, B cell survival and homeostasis, inflammatory diseases, and autoimmunity, there is a lack of clarity about the physiological role of natural IgG and natural IgA because they appear incapable of recognizing Ag…

Safety and Efficacy of Privigen®, a Novel 10% Liquid Immunoglobulin Preparat…

The present study was designed to evaluate the efficacy and safety of a novel, 10% liquid formulation of intravenous immunoglobulin, stabilized with 250 mmol/L L-proline (Privigen®), in patients with primary immunodeficiency disease