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Dysphagia in Acute Stroke: Incidence, Burden and Impact on Clinical Outcome
Reported frequency of post-stroke dysphagia in the literature is highly variable. In view of progress in stroke management, we aimed to assess the current burden of dysphagia in acute ischemic stroke.
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Citicoline for Acute Ischemic Stroke: A Systematic Review and Formal Meta-ana…
Citicoline is a drug approved for the treatment of acute ischemic stroke. Although evidence of its efficacy has been reported, recently published results of a large placebo-controlled clinical trial did not show differences. This study aims to assess whether starting citicoline treatment within 14 days after stroke onset improves the outcome in patients with acute ischemic stroke, as compared …
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Citicoline: pharmacological and clinical review, 2016 update
This review is based on the previous one published in 2010 –Secades JJ. Citicoline: pharmacological and clinical review, 2010 update. Rev Neurol 2011; 52 (Suppl 2): S1-62–, incorporating 183 new references, having all the information available to facilitate the access to the information in one document. This review is focused on the main indications of the drug, as acute stroke and its s…
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Histopathology of diffusion imaging abnormalities in cerebral amyloid angiopathy
We sought to determine the underlying mechanism for altered white matter diffusion tensor imaging (DTI) measures at the histopathologic level in patients with cerebral amyloid angiopathy (CAA).
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Postoperative Cognitive Dysfunction
Older patients in particular are vulnerable to memory disturbances and other types of cognitive impairment after surgical operations. In one study, roughly 12% of patients over age 60 had postoperative cognitive dysfunction (POCD) three months after surgery. This is an important issue in perioperative care as extensive surgery on older patients becomes more common.
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Citicoline: neuroprotective mechanisms in cerebral ischemia
Cytidine-5 ¢-diphosphocholine (citicoline or CDP-choline), an intermediate in the biosynthesis of phosphatidylcholine (PtdCho), has shown bene®cial effects in a number of CNS injury models and pathological conditions of the brain. Citicoline improved the outcome in several phase-III clinical trials of stroke, but provided inconclusive results in recent clinical trials.
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Citicoline for Acute Ischemic Stroke: A Systematic Review and Formal Meta-ana…
Citicoline is a drug approved for the treatment of acute ischemic stroke. Although evidence of its efficacy has been reported, recently published results of a large placebo-controlled clinical trial did not show differences. This study aims to assess whether starting citicoline treatment within 14 days after stroke onset improves the outcome in patients with acute ischemic stroke, as compared w…
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Neuroprotective Properties of Citicoline: Facts, Doubts and Unresolved Issues
Citicoline is the generic name of the pharmaceutical substance that chemically is cytidine-50 -diphosphocholine (CDP-choline), which is identical to the natural intracellular precursor of phospholipid phosphatidylcholine. Following injection or ingestion, citicoline is believed to undergo quick hydrolysis and dephosphorylation to yield cytidine and choline, which then enter the brain separately…
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Therapeutic Applications of Citicoline for Stroke and Cognitive Dysfunction i…
Citicoline (CDP-choline; cytidine 5’-diphosphocholine), a form of the essential nutrient choline, shows promise of clinical efficacy in elderly patients with cognitive deficits, inefficient memory, and early-stage Alzheimer’s disease. Citicoline has also been investigated as a therapy in stroke patients, although the results of trials to date are inconclusive
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Clinical Determinants of Poststroke Dementia
Frequency of poststroke dementia is high, and stroke considerably increases the risk of dementia. The risk factors for dementia related to stroke are still incompletely understood. We sought to examine clinical determinants of poststroke dementia in a large well-defined stroke cohort.
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