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Gagal Ginjal Kronis
Banyak penyakit ginjal yang tidak menunjukkan gejala atau tandaBanyak penyakit ginjal yang tidak menunjukkan gejala atau tanda Banyak penyakit ginjal yang tidak menunjukkan gejala atau tandaBanyak penyakit ginjal yang tidak menunjukkan gejala atau tanda Banyak penyakit ginjal yang tidak menunjukkan gejala atau tandaBanyak penyakit ginjal yang tidak menunjukkan gejala atau tandaBanyak penyakit g…
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Randomized prospective comparison between erythropoietin and androgens in CAP…
Anemia and malnutrition are significant com- served with rHuEPO. Furthermore, compared with rHuEPO, complications in peritoneal dialysis (PD) patients. Previous studies androgen administration was associated with beneficial effects in hemodialysis have shown that androgens are effective as on nutritional status. The mechanism of action of androgens therapy for anemia; however, this has not be…
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International trends in erythropoietin use and hemoglobin levels in hemodialy…
Hemoglobin levels and the dose of erythropoiesisstimulating agents (ESAs) have risen over time in hemodialysis patients within the United States. There are concerns that these trends may be driven by reimbursement policies that provide potential incentives to increase this use. To determine this we studied trends in the use of ESA and hemoglobin levels in hemodialysis patients and the relations…
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Hemoglobin, erythropoietin and systemic inflammation in exacerbations of chro…
In this observational study we have shown that during admission for ECOPD Hb levels are decreased and EPO levels are increased. We have also identified a negative association between Hb and EPO. The above association is mainly related to increased IL-6 levels, indicating a possible EPO resistance through the mechanism of increased systemic inflammatory process.
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Hemoglobin Levels and Erythropoietin Doses in Hemodialysis and Peritoneal Dia…
Erythropoietic agents, a cornerstone of management, are a major component of the cost of renal replacement therapy. The objectives of this study were to compare (on a month-by-month basis) U.S. hemodialysis and peritoneal dialysis patients in terms of the proportion of patients receiving erythropoietin, erythropoietin doses, and hemoglobin levels after initiation of erythropoietin.
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Anaemia in kidney disease: harnessing hypoxia responses for therapy
Improved understanding of the oxygen-dependent regulation of erythropoiesis has provided new insights into the pathogenesis of anaemia associated with renal failure and has led to the development of novel therapeutic agents for its treatment. Hypoxia-inducible factor (HIF)‑2 is a key regulator of erythropoiesis and iron metabolism. HIF‑2 is activated by hypoxic conditions and controls the p…
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Pathophysiology of renal anaemia
Anaemia remains a prominent feature of chronic kidney disease (CKD). The prevalence is inversely correlated with kidney function, and the vast majority of patients with CKD Stage 5 develop anaemia [
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Redefining lupus nephritis: clinical implications of pathophysiologic subtypes
Systemic lupus erythematosus (SLE) is associated with a broad spectrum of clinical and immunologic manifestations, of which lupus nephritis is the most common cause of morbidity and mortality. The development of nephritis in patients with SLE involves multiple pathogenic pathways including aberrant apoptosis, autoantibody production, immune complex deposition and complement activation.
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Redefining lupus nephritis : Clinical Implication of Patophysiologic Subtypes.
Systemic lupus erythematosus (SLE) is associated with a broad spectrum of clinical and immunologic manifestations, of which lupus nephritis is the most common cause of morbidity and mortality. The development of nephritis in patients with SLE involves multiple pathogenic pathways including aberrant apoptosis, autoantibody production, immune complex deposition and complement activation.
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The Efficacy of Darbepoetin Alpha in Hemodialysis Patients Resistant to Human…
Darbepoetin due to longer half life is convenient and effective for long term. This study was done to assess the efficacy of darbepoetin in the treatment of patients on high doses of erythropoietin (EPO) and to compare its efficacy in patients resistant and responsive to EPO. This is a prospective, controlled open label study assessing the efficacy of darbepoetin in 55 hemodialysis patients on …
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