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Clinical profile of levobupivacaine in regional anesthesia: A systematic review
The quest for searching newer and safer anesthetic agents has always been one of the primary needs in anesthesiology practice. Levobupivacaine, the pure S (−)‑enantiomer of bupivacaine, has strongly emerged as a safer alternative for regional anesthesia than its racemic sibling, bupivacaine. Levobupivacaine has been found to be equally efficacious as bupivacaine, but with a superior pharma…
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Update on local anesthetics: focus on levobupivacaine
In recent years levobupivacaine, the pure S (−)-enantiomer of bupivacaine, emerged as a safer alternative for regional anesthesia than its racemic parent. It demonstrated less affi nity and strength of depressant effects onto myocardial and central nervous vital centers in pharmacodynamic studies, and a superior pharmacokinetic profi le. Clinically, levobupivacaine is well tolerated in a vari…
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Levobupivacaine for Pediatric Spinal Anesthesia
In this clinical trial we evaluated the clinical effects of levobupivacaine in spinal anesthesia in children. An open, noncomparative study was performed on 40 children, aged 1–14 yr, undergoing elective lower abdominal or lower limb surgery. A plain solution of S()- bupivacaine 5 mg/mL at a mean dose of 0.3 mg/kg body weight (range, 0.2– 0.5 mg/kg body weight) was administered via the L3…
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