Effects of Probiotics, Prebiotics, and Synbiotics on Human Health

The human gastrointestinal tract is colonised by a complex ecosystem of microorganisms. Intestinal bacteria are not only commensal, but they also undergo a synbiotic co-evolution along with their host. Beneficial intestinal bacteria have numerous and important functions, e.g., they produce various nutrients for their host, prevent infections caused by intestinal pathogens, and modulate a normal…

A comprehensive review on clinical outcome of probiotic and synbiotic therapy…

The composition of gut microflora and its metabolic activity are closely correlated with the host immune system, and the changes in the biometric of the microbiome lead to inflammatory diseases like inflammatory bowel disease. The supplementation of probiotics and synbiotic could indeed manipulate the microflora, which can be an alternative therapy for ulcerative colitis, and Crohn’s disease.

Probiotics: an update on mechanisms of action and clinical applications

Probiotics are live microbial feed supplement and can provide health benefit to the host if administered in sufficient amounts. The most predominant species that have been used as probiotic include Lactobacilli and bifidobacteria. Proper administration of probiotics could be efficient in the treatment of various disorders. However; their mechanism of action is poorly understood

Randomized, placebo-controlled trial on clinical and immunologic effects of p…

A benefi cial role of probiotics, especially Lactobacillus rhamnosus, in children with atopic dermatitis (AD) has been reported. Their effects are primarily mediated through immune pathways, which need further investigation. This study aimed to investigate clinical and immunologic effects of probiotics in the treatment of children with AD

Probiotics: mechanisms and established e!ects

The definition for probiotics has gradually changed with increasing understanding of the mechanisms by which they influence human health. Health e!ects related to changes in the intestinal micro#ora also accompany or are related to adhesion and immune system e!ects, competitive exclusion or metabolic and nutritional e!ects, with an increasing array of other potential modes of action. Most cl…

FACTORS AFFECTING METABOLIC ACTIVITY OF THE INTESTINAL MICROFLORA

The diverse metabolic activities of the mammalian gut microflora are well established (see reviews by Scheline, 1973; Rowland and Walker, 1983; Rowland et al., 1985). It is also clear that many of these reactions catalyzed by the microflora alter the toxicological properties of ingested chemicals and of substances produced by the host and secreted into the gut lumen, for example, bile acids a…

Probiotic Bacteria: Legislative Framework—Requirements to Evidence Basis

Following on from the FAO/WHO Expert Consultation and Working Group outputs on probiotics and their presentation to Codex, it is hoped that these will be used as a science-based risk assessment process for managerial decision on probiotics and that the ‘‘Guidelines for the Evaluation of Probiotics in Food’’ will be used as a model for scientific criteria for evaluation of health claims.…

Probiotics for treatment of acute diarrhoea in children: randomised clinical …

To compare the efficacy of five probiotic preparations recommended to parents in the treatment of acute diarrhoea in children

Guidelines for the Evaluation of Probiotics in Food

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