QUALITY OF LIFE IN EPILEPSY - QOLIE-31 (Version 1.0)

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Treatment of chronic pain: antidepressant, antiepileptic and antiarrhythmic d…

Chronic pain is complex physiologically and there are many influences on the pain experience. The approach to treatment therefore needs to be multimodal, often with a number of different interventions, both physical and psychological, delivered in parallel

EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 re…

This second European Federation of Neurological Societies Task Force aimed at updating the existing evidence about the pharmacological treatment of neuropathic pain since 2005

Evidence-based guideline: Treatment of painful diabetic neuropathy: report of…

Pregabalin is established as effective and should be offered for relief of PDN (Level A). Venlafaxine, duloxetine, amitriptyline, gabapentin, valproate, opioids (morphine sulfate, tramadol, and oxycodone controlled-release), and capsaicin are probably effective and should be considered for treatment of PDN (Level B). Other treatments have less robust evidence or the evidence is negative. Effec…

Pharmacokinetic equivalence study of two formulations of the anticonvulsant p…

The present study was conducted to evaluate whether the bioavailability of pregabalin capsules 150 mg manufactured by PT Dexa Medica was equivalent to the reference formulation.

Pregabalin: Its Pharmacology and Use in Pain Management

Pregabalin is a new synthetic molecule and a structural derivative of the inhibitory neurotransmitter
-aminobutyric acid. It is an 2- (2-) ligand that has analgesic, anticonvulsant, anxiolytic, and sleep-modulating activities. Pregabalin binds potently to the 2- subunit of calcium channels, resulting in a reduction in the release of several neurotransmitters, including glutamate, noradrenalin…