The metabolic syndrome (MetS) can predispose to type 2 diabetes and cardiovascular disease, even it can predict the occurrence of sudden death
Androgensarehormone that plays an importan role in male reproductive system and produced significantly in form of testosterone by Leydig cells in testes and found in circulating throughout the body. The formation of androgens is esensial in a number of androgen action and have specific role for male sexual differentiation and support spermatogenesis in adult rat.
These identified the pubertal increases in serum testosterone in males peaking at 20 years of age and remaining stable thereafter until the eighth decade. In females, circulating testosterone peaked in late adolescence and declined gradually over the next two decades but remained stable across menopause and beyond. After early childhood, serum sex hormone-binding globulin declines to a nadir in…
To review key trials of monotherapy and combination therapy of a1-adrenergic receptor antagonists (a1-ARAs), 5a-reductase inhibitors (5aRIs) and anti-muscarinic agents in the treatment of lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). To assess the safety and efficacy of combination therapies for LUTS associated with BPH, a search of the MEDLINE and Coch…
We investigated the effects of ‘add on’ treatment of a-blocker (AB) on blood pressure (BP) and the safety of ABs in men with symptomatic BPH with or without hypertension. We retrospectively reviewed 2,924 BPH outpatients who took ABs at our institution between 2005 and 2009. BPH symptom severity, prostate volume and BP were determined for 953 patients with their baseline data. BP level and …