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Prospective, randomized study comparing highly purified urinary follicle-stim…
In a randomized study comparing purified urinary FSH with recombinant FSH for IVF/intracytoplasmic sperm injection in patients with polycystic ovary syndrome, there was no significant difference between the mean total dose of FSH used, duration of stimulation, number of retrieved oocytes, number of mature oocytes, number of embryos transferred, or the ongoing pregnancy rate between the two grou…
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Efficacy of recombinant versus human derived follicle stimulating hormone on …
The aim of this trial, comparing human follicle stimulating hormone (hFSH) and recombinant FSH (rFSH) was to evaluate the efficacy on oocyte and embryo quality in in vitro fertilisation/intracytoplasmic sperm injection cycles. Four-hundred and one women were randomised in two groups to receive or hFSH or rFSH in stimulation protocols. The primary end point of this study was the oocyte/embryo qu…
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Urinary follicle-stimulating hormone (FSH) is more effective than recombinant…
The following study was conducted to determine which FSH, recombinant or urinary, works better in older women.
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Long-term efficacy of a triptorelin 3-month depot in girls with central preco…
Three-month gonadotropin-releasing hormone agonists (GnRHas) are expected to achieve better compliance in patients with central precocious puberty (CPP) compared to the monthly formulation. However, 1-month depot remains the dominant choice for conventional treatment worldwide. Our study aimed to investigate the long-term efficacy of a 3-month GnRHa for CPP treatment
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Diagnosis and clinical genetics of Cushing syndrome in pediatrics
Endogenous Cushing syndrome (CS) in pediatrics is rare; it may be caused by tumors that produce corticotropin (ACTH) in the pituitary gland (this form of CS is called Cushing disease) or elsewhere (ectopic CS), tumors that produce corticotropin-releasing hormone (CRH) anywhere (mostly neuroendocrine tissues), and finally adrenocortical masses that produce cortisol, such as adrenocortical cancer…
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Diagnosis and Differential Diagnosis of Cushing’s Syndrome
More than a century ago, Harvey Cushing introduced the term “pluriglandular syndrome” to describe a disorder characterized by rapid development of central obesity, arterial hypertension, proximal muscle weakness, diabetes mellitus, oligomenorrhea, hirsutism, thin skin, and ecchymoses.
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The Investigation of Cushing Syndrome: Essentials in Optimizing Appropriate D…
The investigation of Cushing syndrome (CS) should start with careful history taking and clinical examination, and exogenous steroid usage must be excluded. It is essential to confirm hypercortisolism before further investigations are undertaken. The recommended first-line tests include midnight salivary cortisol and/or the 1 mg overnight or low-dose dexamethasone suppression tests. The next ste…
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The Neuropsychiatric Complications of Glucocorticoid Use: Steroid Psychosis R…
Glucocorticoids are widely prescribed for a variety of diseases and are known to cause neuropsychiatric as well as somatic side effects
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Prevention and management of glucocorticoid-induced side effects: A comprehen…
After completing this learning activity, participants should be able to describe key features of glucocorticoid pharmacology and anticipate, prevent, and manage complications of glucocorticoid use affecting bone health.
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Corticosteroid-induced neuropsychiatric disorders: review and contrast with n…
The aim of this review is to analyze the available literature regarding the neuropsychiatric (NP) disturbances associated with corticosteroid (CS) therapy; to determine the nature, severity, and frequency of these NP symptoms; and to identify the various risk factors involved in the development of CS-induced NP disturbances. We searched the available literature since the advent of corticosteroi…
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