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Understanding the mechanisms of glutamine action in critically ill patients
Glutamine (Gln) is an important energy source and has been used as a supplementary energy substrate. Furthermore, Gln is an essential component for numerous metabolic functions, including acid-base homeostasis, gluconeogenesis, nitrogen transport and synthesis of proteins and nucleic acids. Therefore, glutamine plays a significant role in cell homeostasis and organ metabolism
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Therapeutic benefits of glutamine: An umbrella review of meta-analyses
Glutamine may be an essential amino acid in patients with catabolic disease, as it has been demonstrated that circulating glutamine levels drop during critical illness and following major surgery; this may result in an increase in secondary infection risk, recovery time and mortality rates. However, there is much discrepancy in the literature with regards to randomized controlled studies, and t…
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Glutamine dipeptide-supplemented parenteral nutrition improves the clinical o…
Early randomised controlled trials (RCTs) testing whether parenteral nutrition regimens that include glutamine dipeptides improves the outcomes of critically ill patients demonstrated convincingly that this regimen associates with reduced mortality, infections, and hospital stays. However, several new RCTs on the same question challenged this. To resolve this controversy, the present meta-analy…
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Meta-analysis of Glutamine on Immune Function and Post-Operative Complication…
The aim of this meta-analysis was to evaluate the clinical significance of glutamine in the management of patients with colorectal cancer (CRC) after radical operation. Electronic databases, including PubMed, EMBASE, MEDLINE, Cochrane Library, Chinese Biomedical Database (CBM), China National Knowledge Infrastructure (CNKI), VIP medicine information system (VIP), and Wanfang electronic database…
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Postoperative parenteral glutamine supplementation improves the short-term ou…
The clinical utility of glutamine in patients undergoing colorectal cancer (CRC) surgery remains unclear. Therefore, we aimed to investigate the impact of postoperative treatment with glutamine on postoperative outcomes in patients undergoing CRC surgery.
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What is clinical nutrition? Understanding the epistemological foundations of …
Although the therapeutic and economic efficacy of nutrition has been proven, optimal nutritional care is still scarce among hospital and ambulatory patients. Thus malnutrition is still highly prevalent. We identify as an underlying cause the absence of a common understanding of clinical nutrition as a discipline. The aim of this paper is to establish the epistemological foundations of clinical …
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Perioperative fluid management: science, art or random chaos?
As anaesthetists, we like to believe that the i.v. fluid we administer during surgery is based on a careful consideration of the contemporaneous clinical situation in the particular individual under our care. We estimate deficits; we use clinical assessment and haemodynamic monitoring to characterize circulating blood volume, and we respond to changes with fluid challenges and vasopressors
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Perioperative fluid therapy recommendations for major abdominal surgery. Via …
About 230 million patients undergo surgery each year.1 Reported mortality rates for elective non-cardiac surgery range from 1% to 4%.2 Although less than 15% of inpatient procedures are performed in high-risk patients, such patients account for 80% of deaths
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Clinical Nutrition Guidelines and Summaries for Patients
This document is about the development of clinical nutrition guidelines and the importance of summaries of these for patients as well as the need for patient involvement in the development processes, the importance of health literacy and informed decision-making concerning food and nutrition
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