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Gabapentin misuse, abuse and diversion: a systematic review
Since its market release, gabapentin has been presumed to have no abuse potential and subsequently has been prescribed widely off-label, despite increasing reports of gabapentin misuse. This review estimates and describes the prevalence and effects of, motivations behind and risk factors for gabapentin misuse, abuse and diversion.
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Pharmacological Treatment of Diabetic Neuropathic Pain
Neuropathic pain continues to be a difficult and challenging clinical issue to deal with effectively. Painful diabetic polyneuropathy is a complex pain condition that occurs with reasonable frequency in the population and it maybe extremely difficult for clinicians to provide patients with effective analgesia. Chronic neuropathic pain may occur in approximately one of every four diabetic patie…
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Sleep-Disordered Breathing in Epilepsy: Epidemiology, Mechanisms and Treatment
Epilepsy is a group of neurological conditions in which there is a pathological and enduring predisposition to generate recurrentrnseizures. Evidence over the last few decades suggests that epilepsy may be associated with increased sleep-disordered breathing,rnwhich may contribute towards sleep fragmentation, daytime somnolence, reduced seizure control, and cardiovascular-relatedrnmorbidity and…
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Single dose pharmacokinetic equivalence study of two gabapentin preparations …
The geometric mean ratios (90% confidence interval) of the test drug/reference drug for gabapentin were 103.15% (90.38%–117.72%) for AUCt , 103.53% (90.78%–118.07%) for AUCinf, and 108.06% (96.32%–121.24%) for Cmax. The differences in tmax and t1/2 values between the test and reference drug products for gabapentin were not statistically significant. Light-headedness, nausea, and headache …
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Comparative Efficacy and Safety of Six Antidepressants and Anticonvulsants in…
Anticonvulsants and antidepressants are mostly used in management of painful diabetic neuropathy (PDN). However there are few direct comparisons between drugs of these classes, making evidence-based decision-making in the treatment of painful diabetic neuropathy
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EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 re…
Most large RCTs included patients with diabetic polyneuropathies and postherpetic neuralgia, while an increasing number of smaller studies explored other conditions. Drugs generally have similar efficacy in various conditions, except in trigeminal neuralgia, chronic radiculopathy and HIV neuropathy, with level A evidence in support of tricyclic antidepressants (TCA), pregabalin, gabapentin, tr…
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