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Found 5 from your keywords: subject="Fepezil"
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The Efficacy of Licensed-Indication Use of Donepezil and Memantine Monotherap…
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Lockhart IA

Six randomised controlled studies (4 donepezil and 2 memantine) reported use within the licensed indication and had Neuropsychiatric Inventory (NPI) data suitable for meta-analysis. BPSD showed significant improvement with donepezil compared with placebo [weighted mean difference (WMD) in NPI –3.51, 95% confidence interval (CI) –5.75, –1.27], whereas this was not the case for memantine (W…

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Donepezil for dementia due to Alzheimer’s disease (Review)
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Birks JS

Alzheimer’s disease is the most common cause of dementia in older people. One approach to symptomatic treatment of Alzheimer’s disease is to enhance cholinergic neurotransmission in the brain by blocking the action of the enzyme responsible for the breakdown of the neurotransmitter acetylcholine. This can be done by a group of drugs known as cholinesterase inhibitors. Donepezil is a choline…

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Beyond symptomatic effects: potential of donepezil as a neuroprotective agent…
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Kim SH

Alzheimer’s disease (AD) is associated with neurodegenerative changes resulting clinically in progressive cognitive and functional deficits. The only therapies are the cholinesterase inhibitors donepezil, galantamine and rivastigmine and the N-methyl-Daspartate-receptor antagonist memantine. Donepezil acts primarily on the cholinergic system as a symptomatic treatment, but it also has potenti…

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Clinical efficacy and safety of donepezil in the treatment of Alzheimer’s d…
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Zhang N

Donepezil, an acetylcholinesterase inhibitor (AChEI), has been widely used to treat Alzheimer’s disease (AD) in China. However, there are few studies focusing on the efficacy and safety of donepezil in Chinese patients. In this review, we discuss 1) the efficacy of donepezil and its comparison with other AChEIs or memantine, 2) the therapeutic responses to donepezil and its influencing factor…

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Attention Measures of Accuracy, Variability, and Fatigue Detect Early Respons…
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Vila-Castelar C

Donepezil is widely used to treat Alzheimer’s disease (AD), but detecting early response remains challenging for clinicians. Acetylcholine is known to directly modulate attention, particularly under high cognitive conditions, but no studies to date test whether measures of attention under high load can detect early effects of donepezil. We hypothesized that load-dependent attention tasks are …

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