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Antidiabetic effects of fermented soybean products on type 2 diabetes
Historically, the incidence of type 2 diabetes has been lower in Asian populations compared with those in Western countries. One possible reason for the lower incidence among Asians is that they consume fermented soybean products, which are unique to the traditional Asian diet. Some have hypothesized that dietary phytoestrogens and soy peptides in fermented soybean foods consumed in traditi…
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The soy isoflavone genistein reverses oxidative and inflammatory state, neuro…
Treatment of diabetes complications remains a substantial challenge. The aim of this study was to explore the ability of the soy isoflavone genistein in attenuating the signs that follow diabetes onset: nociceptive hypersensitivity, oxidative and inflammatory state,nerve growth factor(NGF)decrease and vascular dysfunctions. Genistein (3 and 6 mg/kg) was administered to C57BL/6J streptozotoci…
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Long-term Effects of Metformin on Diabetes Prevention: Identification of Subg…
We examined the effects of metformin on diabetes prevention and the subgroups that benefited most over 15 years in the Diabetes Prevention Program (DPP) and its follow-up, the Diabetes Prevention Program Outcomes Study (DPPOS).
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Use of Oral Anti-Diabetic Agents in Pregnancy: A Pragmatic Approach
Insulin is the gold standard for treatment of hyperglycemia during pregnancy, when lifestyle measures do not maintain glycemic control during pregnancy. However, recent studies have suggested that certain oral hypoglycemic agents (metformin and glyburide) may be safe and be acceptable alternatives. There are no serious safety concerns with metformin, despite it crossing the placenta.
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Treatment of Diabetes in Older Adults: An Endocrine Society* Clinical Practic…
The objective is to formulate clinical practice guidelines for the treatment of diabetes in older adults.
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KONSENSUS PENGELOLAAN DAN PENCEGAHAN DIABETES MELITUS TIPE 2 DI INDONESIA : 2015
Hiperglikemia adalah suatu kondisi medik berupa peningkatan kadar glukosa dalam darah melebihi batas normal. Hiperglikemia merupakan salah satu tanda khas penyakit diabetes mellitus (DM), meskipun juga mungkin didapatkan pada beberapa keadaan yang lain. Saat ini penelitian epidemiologi menunjukkan adanya kecenderungan peningkatan angka insidensi dan prevalensi DM tipe-2 di berbagai penjuru du…
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Effects of the Disaccharidase Inhibitor Acarbose on Meal and Intravenous Gluc…
To determine whether the effects of the disaccharidase inhibitor Acarbose on glucose tolerance could be solely explained via an action on intestinal nutrient absorption, the effects of this agent and placebo (100 mg p.0.) on intravenous and postprandial glucose tolerance were compared in six normal subjects. Acarbose significantly diminished plasma glucose, insulin, and astrointestinal inhibit…
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Glucose Tolerance: The STOP-NIDDM Trial Disease and Hypertension in Patients …
Three hundred forty-one patients (24%) discontinued their participation prematurely, 211 in the acarbose-treated group and 130 in the placebo group; these patients were also followed up for outcome parameters. Decreasing postprandial hyperglycemia with acarbose was associated with a 49% relative risk reduction in the development of cardiovascular events (hazard ratio [HR], 0.51; 95% confidence …
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