Hospital-acquired pneumonia in ICU

The French Society of Anesthesia and Intensive Care Medicine and the French Society of Intensive Care edited guidelines focused on hospital-acquired pneumonia (HAP) in intensive care unit (ICU). The goal of 16 French-speaking experts was to produce a framework enabling an easier decision-making process for intensivists. The guidelines were related to 3 specific areas related to HAP (prevention…

Early Administration of Antibiotics for Suspected Sepsis

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Sepsis

Sepsis is a clinical syndrome that requires prompt recognition andrncontrol in order to optimize clinical outcomes in patients. It is very relevantrnto surgical practice, as it can affect perioperative patients andrnthose recovering on surgical wards. A working knowledge of sepsisrnis essential to any medical or surgical practitioner, and here werncover the topic with relevance to surgery and t…

Type 2 Myocardial Infarction : JACC Review Topic of the Week

Acute myocardial infarction (MI) can occur from increased myocardial oxygen demand and/or reduced supply in the absence of acute atherothrombotic plaque disruption; a condition called type 2 myocardial infarction (T2MI). As with any MI subtype, there must be clinical evidence of myocardial ischemia to make the diagnosis. This condition is increasingly diagnosed due to the increasing sensitiv…

The risk of seizures among the carbapenems: a meta-analysis

A consensus exists among clinicians that imipenem/cilastatin is the most epileptogenic carbapenem, despite inconsistencies in the literature

A meta-analysis of efficacy and safety of doripenem for treating bacterial in…

The aim of this article is to compare the efficacy and safety of doripenem forbacterial infections.

Mutant Prevention Concentrations of Four Carbapenems against Gram-Negative Rods

We tested the propensities of four carbapenems to select for resistant Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii mutants by determining the mutant prevention concentrations (MPCs) for 100 clinical strains with various ß-lactam phenotypes