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Dobutamine (hydrochloride)
Dobutamine is a synthetic catecholamine used in the treatment of shock and in cardiac stress testing. It is a chiral molecule and both (+) and (-) isomers are pharmacolgically active but there are important differences in their adrenergic receptor subtype selectively
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Ephedrine, dopamine, or dobutamine to treat hypotension with propofol during …
To compare the efficacy of ephedrine, dopamine and dobutamine for circulatory support during thoracic epidural anesthesia after anesthetic induction with propofol.
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Dopexamine, Dobutamine, and Dopamine Increase Splanchnic Blood Flow : What Is…
Inadequate splanchnic perfusion in the critically ill compromises the gut barrier leading to bacterial translocation, which is postulated to cause multiorgan dysfunction and failure. Inotropic agents such as dopexamine, dobutamine, and dopamine may have a role in increasing splanchnic perfusion, thereby protecting this area from further injury
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Comparison of the haemodynamic effects of dopamine and dobutamine in young ch…
Nineteen children, aged 2-54 months, requiring high-dose inotropic support after cardiac surgery, were given either dopamine or dobutamine in a blinded, double crossover, study. Using a pulmonary artery thermistor, right and left atrial cannulae, and pulmonary and femoral arterial catheters, conventional haemodynamic variables were measured hourly over three consecutive 4 h dopamine-dobutamine-…
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Dobutamine Hydrochloride
Dobutamine hydrochloride is available in 20-, 40-, and 100-mL single-dose vials as a concentrate for injection. Each mL contains 12.5 mg of dobutamine (as the hydrochloride), sodium bisulfite 0.24 mg, and hydrochloric acid and/or sodium hydroxide to adjust the pH. Dobutamine hydrochloride concentrate for injection must be diluted further to a concentration not greater than 5 mg/mL before ad…
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Treatment of right heart failure: is there a solution to the problem?
Right heart function is a significant determinant of outcomes across a variety of aetiologies of rightrnventricular (RV) dysfunction. Right heart failure syndrome is characterised by the inability of the rightrnventricle to generate sufficient stroke volume. Management often requires simultaneous execution ofrnmultiple strategies to optimise RV preload, contractility and afterload, while mainta…
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Pressure gradient vs. flow relationships to characterize the physiology of a …
Pressure loss vs. flow curves offer a fundamental fluid dynamic synthesis for describing aortic valve pathophysiology. Severe AS does not consistently behave like an orifice (as suggested by Gorlin) or a resistor, whereas TAVI devices behave like a pure resistor. During peak dobutamine, the ratio of aortic to left ventricular pressures during systolic ejection provides a ‘fractional flow r…
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Preeclampsia and cardiovascular disease: interconnected paths that enable det…
The potent and now longstanding evidence of the association between placentationrelated disorders and cardiovascular disease should be translated into clinical practice in order to introduce a preventive approach to future obstetric and cardiovascular diseases. The purpose of this review is to integrate cardiovascular risk/disease and obstetric complications, which are linked by endothelial dy…
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