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Flunarizine in the prophylaxis of migrainous vertigo: a randomized controlled…
Migrainous vertigo is a common cause of dizziness presenting to an otorhinolaryngology/otoneurology clinic. Although it causes a substantial burden to the individual and society there are no randomized controlled trails on prophylactic medication for this condition. Flunarizine, a calcium channel blocker has been used effectively in both migraine and vestibular conditions. This randomized c…
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Flunarizine versus betahistine in vertigo: a systematic review
We systematically searched electronic databases from the Cochrane Library, PubMed, Trip Database and Scopus. The other resource that we searched included web directory (google scholar). We also made hand searching. We included the previous randomized controlled trials (RCTs) regarding the efficacy of flunarizine comparing with betahistine. Our primary outcome was vegetative symptoms improvement…
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European Headache Federation (EHF) critical re-appraisal and meta-analysis of…
Novel disease‑specific and mechanism‑based treatments sharing good evidence of efficacy for migraine have been recently marketed. However, reimbursement by insurers depends on treatment failure with classic anti‑migraine drugs. In this systematic review and meta‑analysis, we aimed to identify and rate the evidence for efficacy of flunarizine, a repurposed, first‑ or second‑line trea…
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Flunarizine: a review of its role in migraine prophylaxis
Flunarizine, a potent calcium channel blocker has been used for more than three decades for the prophylactic management of migraine. Theories suggest that flunarizine may act through multiple mechanisms such as inhibition of cortical spreading depression, neurogenic inflammation and channelopathy. Flunarizine is efficacious in the management of various types of migraines such as common, classic…
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Can flunarizine be used routinely as the first option for childhood headache …
The prevalence of headache in childhood increases due to environmental factors. Various risk factors in children whose playgrounds are restricted outside and therefore remain inactive. So diagnosis and treatment can be challenging. The aim of this study was to evaluate the experience of flunarizine in childhood headache with a focus on efficacy and success
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