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Long-term Effects of Metformin on Diabetes Prevention: Identification of Subg…
We examined the effects of metformin on diabetes prevention and the subgroups that benefited most over 15 years in the Diabetes Prevention Program (DPP) and its follow-up, the Diabetes Prevention Program Outcomes Study (DPPOS).
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Strategies for Diabetes Management: Using Newer Oral Combination Therapies Ea…
The duration of uncontrolled type 2 diabetes mellitus (T2DM) can adversely impact small and large vessels, eventually leading to microvascular and macrovascular complications. Failure of therapeutic lifestyle changes, monotherapy, and clinical inertia contribute to persistent hyperglycemia and disease progression.
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Use of Oral Anti-Diabetic Agents in Pregnancy: A Pragmatic Approach
Insulin is the gold standard for treatment of hyperglycemia during pregnancy, when lifestyle measures do not maintain glycemic control during pregnancy. However, recent studies have suggested that certain oral hypoglycemic agents (metformin and glyburide) may be safe and be acceptable alternatives. There are no serious safety concerns with metformin, despite it crossing the placenta.
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Treatment of Diabetes in Older Adults: An Endocrine Society* Clinical Practic…
The objective is to formulate clinical practice guidelines for the treatment of diabetes in older adults.
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KONSENSUS PENGELOLAAN DAN PENCEGAHAN DIABETES MELITUS TIPE 2 DI INDONESIA : 2015
Hiperglikemia adalah suatu kondisi medik berupa peningkatan kadar glukosa dalam darah melebihi batas normal. Hiperglikemia merupakan salah satu tanda khas penyakit diabetes mellitus (DM), meskipun juga mungkin didapatkan pada beberapa keadaan yang lain. Saat ini penelitian epidemiologi menunjukkan adanya kecenderungan peningkatan angka insidensi dan prevalensi DM tipe-2 di berbagai penjuru du…
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Effects of Pioglitazone and Rosiglitazone on Blood Lipid Levels and Glycemic …
The antihyperglycemic effects of pioglitazone hydrochloride and rosiglitazone maleate are well documented. The results of clinical trials and observational studies have suggested, however, that there are individual differences in the effects of these drugs on blood lipid levels.
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Efficacy and Tolerability of Pioglitazone in Patients with Type 2 Diabetes Me…
Diabetes mellitus is a debilitating disease that is estimated to affect 366 million people by the year 2030. Type 2 diabetes mellitus (T2DM) is characterized by a progressive decline in pancreatic b-cell function and increased insulin resistance, and accounts for approximately 90% of people with diabetes. Oral antihyperglycaemic agents are extensively used in the treatment of T2DM. Thiazolidine…
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Effect of Pioglitazone on Abdominal Fat Distribution and Insulin Sensitivity …
We examined the effect of pioglitazone on abdominal fat distribution to elucidate the mechanisms via which pioglitazone improves insulin resistance in patients with type 2 diabetes mellitus. Thirteen type 2 diabetic patients (nine men and four women; age, 52 3 yr; body mass index, 29.0 1.1 kg/m2), who were being treated with a stable dose of sulfonylurea (n 7) or with diet alone (n 6…
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