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Celecoxib pharmacogenetics and pediatric adenotonsillectomy: a double-blinded…
Pediatric adenotonsillectomy (A&T) is associated with prolonged pain and functional limitation. Celecoxib is an effective analgesic in adult surgery patients; however, its analgesic efficacy on pain and functional recovery in pediatric A&T patients is unknown
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Perioperative celecoxib administration for pain management after total knee a…
Non-steroidal anti-inflammatory drugs (NSAIDs) are recommended for multimodal postoperative pain management. We evaluated opioid-sparing effects and rehabilitative results after perioperative celecoxib administration for total knee arthroplasty
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Effect of short-term postoperative celecoxib administration on patient outcom…
Non-opioid analgesics are increasingly used as part of a multimodal regimen for pain management. This prospective, randomized, double-blinded, placebo-controlled study was designed to evaluate the effect of short-term postoperative administration of celecoxib on pain management and recovery outcomes following laparoscopic surgery.
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Randomised clinical trial: gastrointestinal events in arthritis patients trea…
We evaluated GI safety of celecoxib compared with 2 nonselective (ns) NSAIDs, as a secondary objective of a large trial examining multiorgan safety. Methods: This randomised, double-blind controlled trial analysed 24 081 patients. Osteoarthritis or rheumatoid arthritis patients, needing ongoing NSAID treatment, were randomised to receive celecoxib 100-200 mg b.d., ibuprofen 600-800 mg t.d.s. o…
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An Update on the Pathology and Clinical Management of Gouty Arthritis
Gouty arthritis is an inflammatory disease initially triggered by the deposition of monosodium urate crystals into the joint space, developing into an inflammatory cascade resulting in the secretion of several proinflammatory cytokines and neutrophil recruitment into the joint. It is associated with debilitating clinical symptoms, functional impairments, and a substantial impact on quality-of-life
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