Assessing the severity of acute pulmonary embolism-manuscript-2019

Acute pulmonary embolism (PE) is potentially fatal due either to a first massive episode or early recurrence; however, if diagnosed early, it can be effectively treated and in most cases cured. PE episodes have a wide spectrum of severity: from asymptomatic, detected incidentally to life-threatening with haemodynamic collapse. Consequently, optimal treatment may range from anticoagulant pills t…

Risk Factors for Stroke in the Chinese Population

Stroke is the leading cause of death in China. According to the Chinese Stroke Screening and Prevention Project, 8 main risk factors were assessed and individuals with 3 or more risk factors were identified as high-risk population of stroke. To explore the potential impropriety of counting the risk factors but ignoring the different strength of association of each risk factor, we performed thi…

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The nephrotic syndrome: pathogenesis and treatment of edema formation and sec…

Nephrotic syndrome is an important clinical condition affecting both children and adults. Studies suggest that the pathogenesis of edema in individual patients may occur via widely variable mechanisms, i.e., intravascular volume underfilling versus overfilling. Managing edema should therefore be directed to the underlying pathophysiology. Nephrotic syndrome is also associated with clinically …

Pulmonary hypertension associated with left heart disease: Updated Recommenda…

In the summer of 2016, delegates from the German Society of Cardiology (DGK), the German Respiratory Society (DGP), and the German Society of Pediatric Cardiology (DGPK) met in Cologne, Germany, to define consensus-based practice recommendations for the management of patients with pulmonary hypertension (PH).

How I treat children with haemophilia and inhibitors

Haemophilia is a serious inherited bleeding disorder resulting from a deficiency of coagulation factor VIII (haemophilia A) or coagulation factor IX (haemophilia B). While effective therapies have been developed to replace the missing factor and restore normal coagulation, they can lead to the development of neutralizing anti-drug antibodies, termed inhibitors, which significantly worsen morbid…

Genetics of NO Deficiency

Nitric oxide-cyclic guanosine monophosphate (NO-cGMP) deficiency has been associated with an increased risk for cardiovascular disease (CVD).1,2 The term NO-cGMP de- ficiency refers to conditions that lead to the impaired bioavailability and bioactivity of NO and/or cGMP and involves mechanisms including endothelial NO-synthase (eNOS) substrate deficiency and/or competition, eNOS defects and/…

Risk of recurrent venous thromboembolism after acute pulmonary embolism: role…

There is conflicting evidence regarding the role of residual pulmonary obstruction (RPO) or persistent right ventricular dysfunction (RVD) after pulmonary embolism (PE) as a predictor of recurrent venous thromboembolism (VTE). The aim of this study was to assess whether RPO or persistent RVD after PE is associated with recurrent VTE

Nitric oxide in fungi: is there NO light at the end of the tunnel?

Nitric oxide (NO) is a remarkable gaseous molecule with multiple and important roles in different organisms, including fungi. However, the study of the biology of NO in fungi has been hindered by the lack of a complete knowledge on the different metabolic routes that allow a proper NO balance, and the regulation of these routes. Fungi have developed NO detoxification mechanisms to combat nitr…

Recovery From Heart Attack, Biomedicalization, and the Production of a Contin…

In this article, I explore the experience of recovery from a heart attack through an analytic autoethnography. I Discuss the tensions inherent in biomedical subjectivities of health and ill-health during cardiac recovery through three key themes