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Phase III randomized clinical trial of efficacy and safety of amlodipine and …
Effective antihypertensive therapy is essential for achieving optimal blood pressure (BP) control and reducing cardiovascular events. This double-blind, multicenter, randomized trial aimed to compare the antihypertensive efficacy and safety of a combination of amlodipine (AML) and candesartan cilexetil (CC) versus AML monotherapy in patients with essential hypertension (HTN). After a 4-week run…
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Cytokine storm in Covid-19-Immunopathological mechanisms, clinical considerat…
Cytokine storm is an acute hyperinflammatory response that may be responsible for critical illness inmany conditions including viral infections, cancer, sepsis, andmulti-organ failure. The phenomenon has been implicated in critically ill patients infected with SARS-CoV-2, the novel coronavirus implicated in COVID-19. Critically ill COVID-19 patients experiencing cytokine storm are believed to …
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Practical management of peripartum cardiomyopathy
Peripartum cardiomyopathy (PPCM) is an idiopathic cardiomyopathy that causes systolic heart failure (HF) in previously healthy young women. Despite latest remarkable achievement, unifying pathophysiologic mechanism is not well established. Considering close temporal relationship to pregnancy, the recent prolactin theory is promising.
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Effects of candesartan and amlodipine on cardiovascular events in hypertensiv…
We examined the effects of candesartan and amlodipine on cardiovascular events in hypertensive patients with chronic kidney disease (CKD) using the data from the Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) trial. CKD was defined as proteinuria and/or decreased GFR (o60 ml per min per 1.73m2) at enrollment. Among 2720 subjects with CKD, there were 1376 and 1344 patients…
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Efficacy and Tolerability of Combination Therapy Versus Monotherapy with Cand…
Intensive blood pressure (BP)lowering is important for the treatment of hypertension; however, it has been a challenge to achieve target BP in many patients. The purpose of this study was to explore the optimal dosage of a fixed-dose combination o candesartan cilexetil (CAN) and amlodipine besylate (AML),by examining the tolerability and efficacy of CAN/AML combination therapy compared with th…
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Evaluation of the Efficacy and Tolerability of Combination Therapy With Cande…
Blood pressure is reported to be insufficiently controlledin>50% of patients with hypertension. Guidelines for the management of hypertension recommend using drugs with different mechanisms of action when >1 agent is needed to achieve the blood pressure target. The combination of an angiotens inreceptor blocker and a calcium channel blockeris recommended asthe preferred antihypertensive medicat…
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Sartan- AT receptor interactions: evidence for insurmountable antagonism and …
Sartans are non-peptide AT1 receptor antagonists used to treat hypertension and related pathologies. Their effects on the G protein-dependent responses of angiotensin II (Ang II) were the same in vascular tissues and in isolated cell systems. All are competitive but, when pre-incubated, they act surmountably (only rightward shift of the Ang II concentration-response curve) or insurmountably (a…
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Bioequivalence study of two formulations of candesartan cilexetil tablet in h…
This study was a randomized, single- blind, two-period, cross-over study which included 24 healthy adult male and female subjects under fasting conditions. The pharmacokinetic parameters were determined based on the concentrations of candesartan (CAS 139481-59-7), using ultra-pressure high-performance liquid chromatography with a tandem mass spectrometer detector. In each of the two study perio…
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Effect of Amlodipine + Candesartan on Cardiovascular Events in Hypertensive P…
Combination therapy with calcium channel blockers and angiotensin II receptor blockers is recommended as one of the effective therapies for hypertension. However, it remains unclear whether this combination reduces major adverse cardiovascular events (MACEs) in patients with hypertension with coronary artery disease (CAD). The purpose of the present study was to examine the effects of amlod…
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