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Gastric Cancer:Risk Factors, Diagnosis and Management
Gastric cancer (GC) is the most common cancer with high mortality worldwide.Highrate of GC deaths reported in China, Japan, and Korea. There are 56% new cases from Eastern Asia,41% from China,and11% from Japan. The common causes of GC include Helicobacter pylori infection which accounts for 60% of cases, pickled vegetables, smoking, alcohol intake and genetics. GC is often asymptomatic or nonsp…
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Gastric cancer: epidemiology, prevention, classification, and treatment
Gastric cancer is the second most common cause of cancer-related deaths in the world, the epidemiology of which has changed within last decades. A trend of steady decline in gastric cancer incidence rates is the effect of the increased standards of hygiene, conscious nutrition, and Helicobacter pylori eradication, which together constitute primary prevention. Avoidance of gastric cancer remain…
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Capecitabine Versus Active Monitoring in Stable or Responding Metastatic Colo…
Despite extensive randomized evidence supporting the use of treatment breaks in metastatic colorectal cancer (mCRC), they are not universally offered to patients despite improvements in quality of life without detriment to overall survival (OS). FOCUS4-N was set up to explore the impact of oral maintenance therapy in patients who are responding to first-line therapy
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Adjuvant Capecitabine for Breast Cancer after Preoperative Chemotherapy
Patients who have residual invasive carcinoma after the receipt of neoadjuvant chemotherapy for human epidermal growth factor receptor 2 (HER2)–negative breast cancer have poor prognoses. The benefit of adjuvant chemotherapy in these patients remains unclear.
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Oral Capecitabine Compared With Intravenous Fluorouracil Plus Leucovorin in P…
To compare the efficacy and safety of orally administered capecitabine (Xeloda; Roche Laboratories, Inc, Nutley, NJ), a novel fluoropyrimidine carbamate designed to mimic continuous fluorouracil (5-FU) infusion but with preferential activation at the tumor site, with that of intravenous (IV) 5-FU plus leucovorin (5-FU/LV) as first-line treatment for metastatic colorectal cancer
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Superior Survival With Capecitabine Plus Docetaxel Combination Therapy in Ant…
Docetaxel and capecitabine, a tumor-activated oral fluoropyrimidine, show high single-agent efficacy in metastatic breast cancer (MBC) and synergy in preclinical studies. This international phase III trial compared efficacy and tolerability of capecitabine/docetaxel therapy with single-agent docetaxel in anthracycline- pretreated patients with MBC.
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Clinical Management of Localized Colon Cancer with Capecitabine
Large randomized trials demonstrated a benefit of adjuvant chemotherapy after resection of the primary colon cancer. It improves overall survival and reduces the risk of death, by 5% in UICC (Union Internationale Contre le Cancer) stage II and approximately 15%–20% in stage III. Fluoropyrimidines have been the standard drugs for the treatment of colon cancer since large randomized controlled …
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