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Leveraging natural killer cells for cancer immunotherapy
Natural killer (NK) cells are potent antitumor effector cells of the innate immune system. Based on their ability to eradicate tumors in vitro and in animal models, significant enthusiasm surrounds the prospect of leveraging human NK cells as vehicles for cancer immunotherapy. While interest in manipulating the effector functions of NK cells has existed for over 30 years, there is renewed opti…
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Tailoring Natural Killer cell immunotherapy to the tumour microenvironment
Natural killer (NK) cells are cytotoxic and cytokine-secreting cells that can mediate potent anti-tumour activity. Accumulating evidence indicates that NK cell functions are severely compromised within the confines of the tumour microenvironment thus impairing the efficacy and development of NK cell-based therapies. Here we review the various cellular and molecular pathways that tumours have…
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THE CONCEPTUAL AND CLINICAL PROBLEMS OF PARANEOPLASTIC SYNDROME IN ONCOLOGY A…
Symptomatology of oncological diseases consists not only of local symptoms caused by the primary malignancy or its metastases, but also by general systemic signs that are not directly connected with the tumor. These symptoms are mostly associated with autoimmunity or endocrine influences. In many cases, the source of paraneoplastic syndromes (PNS) is unknown. Nearly 15% of oncological patients …
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Honk if You Love Rad Onc! OMG—What About Your QMP?
Recent figures as of December 2013 indicate that the ACR’s membership is 36,605, or 74% of all US radiologists, including 1,159 radiation oncologists (3%) and 634 medical physicists (1%). The number of radiation oncologists and physicsts is small, but these members make large contributions to the College and the profession.
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Delays for diagnosis and treatment of lung cancers: a systematic review
Lung cancer, and particularly non-small cell lung cancer (NSCLC), which represents ∼80% of lung cancers, is a considerable public health problem (1) because it is an important burden in terms of morbidity and mortality.
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Timeliness of Access to Lung Cancer Diagnosis and Treatment: A Scoping Litera…
The Institute of Medicine recently called for increased understanding of and commitment to timely care. Lung cancer can be difficult to diagnose, resulting in delays that may adversely affect survival; rapid diagnosis and treatment therefore is critical for enabling improved patient outcomes. This scoping review provides an update on timeliness of lung cancer care over the past decade.
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Tailoring Natural Killer cell immunotherapy to the tumour microenvironment
Natural killer (NK) cells are cytotoxic and cytokine-secreting cells that can mediate potent anti-tumour activity. Accumulating evidence indicates that NK cell functions are severely compromised within the confines of the tumour microenvironment thus impairing the efficacy and development of NK cell-based therapies. Here we review the various cellular and molecular pathways that tumours have…
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THE CONCEPTUAL AND CLINICAL PROBLEMS OF PARANEOPLASTIC SYNDROME IN ONCOLOGY A…
Symptomatology of oncological diseases consists not only of local symptoms caused by the primary malignancy or its metastases, but also by general systemic signs that are not directly connected with the tumor. These symptoms are mostly associated with auto-immunity or endocrine influences. In many cases, the source of paraneoplastic syndromes (PNS) is unknown. Nearly 15% of on-cological patient…
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Immunotherapy in Lung Cancer
Lung cancer is the leading cause of cancer-related mortality in the United States.1 Non–small cell lung cancer (NSCLC) comprises approximately 85% of all lung cancer cases.2 Among patients with NSCLC, approximately 40% present with stage IV disease. 3 Although targeted therapy has been associated with a significant benefit in patients harboring aberrations in epidermal growth factor receptor…
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Paraneoplastic Syndromes: An Approach to Diagnosis and Treatment
Recent medical advances have improved the understanding, diagnosis, and treatment of paraneoplastic syndromes. These disorders arise from tumor secretion of hormones, peptides, or cytokines or from immune cross-reactivity between malignant and normal tissues. Paraneoplastic syndromes may affect diverse organ systems, most notably the endocrine, neurologic, dermatologic, rheumatologic, and hemat…
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