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The Clinical Pharmacology of Non-sedating Antihistamines
We previously reported on brain H1 receptor occupancy measurements of antihistamines in human brain using [11C]doxepin and positron emission tomography (PET). We proposed the use of brain H1 receptor occupancy to classify antihistamines objectively into three categories of sedating, less-sedating, and non-sedating antihistamines according to their sedative effects. Non-sedating antihistamines a…
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Loratadine Versus Cetirizine: Assessment of Somnolence and Motivation During …
This parallel-group, double-blind study compared the somnolence and motivation profiles of 2 second-generation antihistamines, loratadine and cetirizine, in pattents with allergic rhinitis.
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Allergic rhinitis and asthma: How important is the link?
Dysfunction of the upper and lower airways frequently coexist, and they appear to share key elements of pathogenesis. Data from epidemiologic studies indicate that nasal symptoms are experienced by as many as 78% of patients with asthma and that asthma is experienced by as many as 38% of patients with allergic rhinitis. Studies also have identified a temporal relation between the onset of rh…
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Antihistamines General Statement
Antihistamines, which inhibit the effects of histamine at H1 receptors, have been classified as first generation (i.e., relatively sedating) or second generation (i.e., relatively nonsedating).
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